Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra

Cerebral dopamine neurotrophic factor (CDNF) protects the nigrostriatal dopaminergic (DA) neurons in rodent models of Parkinson’s disease and restores DA circuitry when delivered after these neurons have begun to degenerate. These DA neurons have been suggested to transport striatal CDNF retrogradel...

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Bibliografske podrobnosti
izdano v:eNeuro
Main Authors: Mätlik, Kert, Vihinen, Helena, Bienemann, Ali, Palgi, Jaan, Voutilainen, Merja H., Booms, Sigrid, Lindahl, Maria, Jokitalo, Eija, Saarma, Mart, Huttunen, Henri J., Airavaara, Mikko, Arumäe, Urmas
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2017
Teme:
New Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318544/
https://ncbi.nlm.nih.gov/pubmed/28275710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0128-16.2017
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