Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra

Cerebral dopamine neurotrophic factor (CDNF) protects the nigrostriatal dopaminergic (DA) neurons in rodent models of Parkinson’s disease and restores DA circuitry when delivered after these neurons have begun to degenerate. These DA neurons have been suggested to transport striatal CDNF retrogradel...

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Dettagli Bibliografici
Pubblicato in:eNeuro
Autori principali: Mätlik, Kert, Vihinen, Helena, Bienemann, Ali, Palgi, Jaan, Voutilainen, Merja H., Booms, Sigrid, Lindahl, Maria, Jokitalo, Eija, Saarma, Mart, Huttunen, Henri J., Airavaara, Mikko, Arumäe, Urmas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2017
Soggetti:
New Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318544/
https://ncbi.nlm.nih.gov/pubmed/28275710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0128-16.2017
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