Transient transfection of human CDNF gene reduces the 6-hydroxydopamine-induced neuroinflammation in the rat substantia nigra

BACKGROUND: The anti-inflammatory effect of the cerebral dopamine neurotrophic factor (CDNF) was shown recently in primary glial cell cultures, yet such effect remains unknown both in vivo and in 6-hydroxydopamine (6-OHDA) models of Parkinson’s disease (PD). We addressed this issue by performing an...

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Detalles Bibliográficos
Publicado en:J Neuroinflammation
Autores principales: Nadella, Rasajna, Voutilainen, Merja H, Saarma, Mart, Gonzalez-Barrios, Juan A, Leon-Chavez, Bertha A, Jiménez, Judith M Dueñas, Jiménez, Sergio H Dueñas, Escobedo, Lourdes, Martinez-Fong, Daniel
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4275959/
https://ncbi.nlm.nih.gov/pubmed/25511018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-014-0209-0
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