Recombinant adeno-associated virus 2/5-mediated gene transfer is reduced in the aged rat midbrain

Clinical trials are examining the efficacy of viral vector-mediated gene delivery for treating Parkinson’s disease (PD). While viral vector strategies have been successful in preclinical studies, to date clinical trials have disappointed. This may be due to the fact that preclinical studies fail to...

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Udgivet i:Neurobiol Aging
Main Authors: Polinski, Nicole K., Gombash, Sara E., Manfredsson, Fredric P., Lipton, Jack W., Kemp, Christopher J., Cole-Strauss, Allyson, Kanaan, Nicholas M., Steece-Collier, Kathy, Kuhn, Nathan C., Wohlgenant, Susan L., Sortwell, Caryl E.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4315740/
https://ncbi.nlm.nih.gov/pubmed/25457558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2014.07.047
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