Subthalamic Nucleus Deep Brain Stimulation Does Not Modify the Functional Deficits or Axonopathy Induced by Nigrostriatal α-Synuclein Overexpression

Subthalamic nucleus deep brain stimulation (STN DBS) protects dopaminergic neurons of the substantia nigra pars compacta (SNpc) against 6-OHDA and MPTP. We evaluated STN DBS in a parkinsonian model that displays α-synuclein pathology using unilateral, intranigral injections of recombinant adeno-asso...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Fischer, D. Luke, Manfredsson, Fredric P., Kemp, Christopher J., Cole-Strauss, Allyson, Lipton, Jack W., Duffy, Megan F., Polinski, Nicole K., Steece-Collier, Kathy, Collier, Timothy J., Gombash, Sara E., Buhlinger, Daniel J., Sortwell, Caryl E.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703955/
https://ncbi.nlm.nih.gov/pubmed/29180681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16690-x
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