Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons

Increased α-synuclein (αsyn) and mitochondrial dysfunction play central roles in the pathogenesis of Parkinson’s disease (PD), and lowering αsyn is under intensive investigation as a therapeutic strategy for PD. Increased αsyn levels disrupt mitochondria and impair respiration, while reduced αsyn pr...

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Publicat a:eNeuro
Autors principals: Pathak, Divya, Berthet, Amandine, Bendor, Jacob T., Yu, Katharine, Sellnow, Rhyomi C., Orr, Adam L., Nguyen, Mai K, Edwards, Robert H., Manfredsson, Fredric P., Nakamura, Ken
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2017
Matèries:
Negative Results
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409983/
https://ncbi.nlm.nih.gov/pubmed/28462393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0216-16.2017
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