Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity

Human studies and preclinical models of Parkinson’s disease implicate the involvement of both the innate and adaptive immune systems in disease progression. Further, pro-inflammatory markers are highly enriched near neurons containing pathological forms of alpha synuclein (α-syn), and α-syn overexpr...

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Detaylı Bibliyografya
Yayımlandı:Front Mol Neurosci
Asıl Yazarlar: Benskey, Matthew J., Sellnow, Rhyomi C., Sandoval, Ivette M., Sortwell, Caryl E., Lipton, Jack W., Manfredsson, Fredric P.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2018
Konular:
Neuroscience
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5819572/
https://ncbi.nlm.nih.gov/pubmed/29497361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00036
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