A comparative study of the binding properties, dipeptidyl peptidase‐4 (DPP‐4) inhibitory activity and glucose‐lowering efficacy of the DPP‐4 inhibitors alogliptin, linagliptin, sax...

door Berger, Joel P., SinhaRoy, Ranabir, Pocai, Alessandro, Kelly, Theresa M., Scapin, Giovanna, Gao, Ying‐Duo, Pryor, Kelly Ann D., Wu, Joseph K., Eiermann, George J., Xu, Shiyao S., Zhang, Xiaoping, Tatosian, Daniel A., Weber, Ann E., Thornberry, Nancy A., Carr, Richard D.
Gepubliceerd in Endocrinol Diabetes Metab (2017)

Selective Small-Molecule Agonists of G Protein–Coupled Receptor 40 Promote Glucose-Dependent Insulin Secretion and Reduce Blood Glucose in Mice

door Tan, Carina P., Feng, Yue, Zhou, Yun-Ping, Eiermann, George J., Petrov, Aleksandr, Zhou, Changyou, Lin, Songnian, Salituro, Gino, Meinke, Peter, Mosley, Ralph, Akiyama, Taro E., Einstein, Monica, Kumar, Sanjeev, Berger, Joel P., Mills, Sander G., Thornberry, Nancy A., Yang, Lihu, Howard, Andrew D.
Gepubliceerd in 2008

Stimulation of Glucose-Dependent Insulin Secretion by a Potent, Selective sst(3) Antagonist

door Pasternak, Alexander, Feng, Zhe, de Jesus, Reynalda, Ye, Zhixiong, He, Shuwen, Dobbelaar, Peter, Bradley, Scott A., Chicchi, Gary G., Tsao, Kwei-Lan, Trusca, Dorina, Eiermann, George J., Li, Cai, Feng, Yue, Wu, Margaret, Shao, Qing, Zhang, Bei B., Nargund, Ravi, Mills, Sander G., Howard, Andrew D., Yang, Lihu, Zhou, Yun-Ping
Gepubliceerd in 2012

Diamine Derivatives as Novel Small-Molecule, Potent, and Subtype-Selective Somatostatin SST3 Receptor Agonists

door Li, Derun, Wu, Zhicai, Yu, Yang, Ball, Richard G., Guo, Liangqin, Sherer, Edward, He, Shuwen, Hong, Qingmei, Lai, Zhong, Qi, Hongbo, Truong, Quang, Yang, David X., Chicchi, Gary G., Tsao, Kwei-Lan, Trusca, Dorina, Trujillo, Maria, Pachanski, Michele, Eiermann, George J., Howard, Andrew D., Zhou, Yun-Ping, Zhang, Bei B., Nargund, Ravi P., Hagmann, William K.
Gepubliceerd in 2014

Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes

door Guo, Liangqin, Parker, Dann L., Zang, Yi, Sweis, Ramzi F., Liu, Weiguo, Sherer, Edward C., Buist, Nicole, Terebetski, Jenna, Kelly, Terri, Bugianesi, Randal, Priest, Birgit T., Dingley, Karen H., Li, Xiaofang, Mitelman, Stan, Salituro, Gino, Trujillo, Maria E., Pachanski, Michele, Kirkland, Melissa, Powles, Mary Ann, Eiermann, George J., Feng, Yue, Shang, Jin, Howard, Andrew D., Ujjainwalla, Feroze, Sinz, Christopher J., Debenham, John S., Edmondson, Scott D., Nargund, Ravi P., Hagmann, William K., Li, Derun
Gepubliceerd in ACS Med Chem Lett (2016)

Investigation of Cardiovascular Effects of Tetrahydro-β-carboline sstr3 antagonists

door He, Shuwen, Lai, Zhong, Ye, Zhixiong, Dobbelaar, Peter H., Shah, Shrenik K., Truong, Quang, Du, Wu, Guo, Liangqin, Liu, Jian, Jian, Tianying, Qi, Hongbo, Bakshi, Raman K., Hong, Qingmei, Dellureficio, James, Reibarkh, Mikhail, Samuel, Koppara, Reddy, Vijay B., Mitelman, Stan, Tong, Sharon X., Chicchi, Gary G., Tsao, Kwei-Lan, Trusca, Dorina, Wu, Margaret, Shao, Qing, Trujillo, Maria E., Fernandez, Guillermo, Nelson, Donald, Bunting, Patricia, Kerr, Janet, Fitzgerald, Patrick, Morissette, Pierre, Volksdorf, Sylvia, Eiermann, George J., Li, Cai, Zhang, Bei, Howard, Andrew D., Zhou, Yun-Ping, Nargund, Ravi P., Hagmann, William K.
Gepubliceerd in 2014

Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia

door Yin, Wu, Carballo-Jane, Ester, McLaren, David G., Mendoza, Vivienne H., Gagen, Karen, Geoghagen, Neil S., McNamara, Lesley Ann, Gorski, Judith N., Eiermann, George J., Petrov, Aleksandr, Wolff, Michael, Tong, Xinchun, Wilsie, Larissa C., Akiyama, Taro E., Chen, Jing, Thankappan, Anil, Xue, Jiyan, Ping, Xiaoli, Andrews, Genevieve, Wickham, L. Alexandra, Gai, Cesaire L., Trinh, Tu, Kulick, Alison A., Donnelly, Marcie J., Voronin, Gregory O., Rosa, Ray, Cumiskey, Anne-Marie, Bekkari, Kavitha, Mitnaul, Lyndon J., Puig, Oscar, Chen, Fabian, Raubertas, Richard, Wong, Peggy H., Hansen, Barbara C., Koblan, Ken S., Roddy, Thomas P., Hubbard, Brian K, Strack, Alison M.
Gepubliceerd in 2012

The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes

door He, Shuwen, Ye, Zhixiong, Truong, Quang, Shah, Shrenik, Du, Wu, Guo, Liangqin, Dobbelaar, Peter H., Lai, Zhong, Liu, Jian, Jian, Tianying, Qi, Hongbo, Bakshi, Raman K., Hong, Qingmei, Dellureficio, James, Pasternak, Alexander, Feng, Zhe, deJesus, Reynalda, Yang, Lihu, Reibarkh, Mikhail, Bradley, Scott A., Holmes, Mark A., Ball, Richard G., Ruck, Rebecca T., Huffman, Mark A., Wong, Frederick, Samuel, Koppara, Reddy, Vijay B., Mitelman, Stan, Tong, Sharon X., Chicchi, Gary G., Tsao, Kwei-Lan, Trusca, Dorina, Wu, Margaret, Shao, Qing, Trujillo, Maria E., Eiermann, George J., Li, Cai, Zhang, Bei B., Howard, Andrew D., Zhou, Yun-Ping, Nargund, Ravi P., Hagmann, William K.
Gepubliceerd in 2012

Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes

door Shah, Shrenik K., He, Shuwen, Guo, Liangqin, Truong, Quang, Qi, Hongbo, Du, Wu, Lai, Zhong, Liu, Jian, Jian, Tianying, Hong, Qingmei, Dobbelaar, Peter, Ye, Zhixiong, Sherer, Edward, Feng, Zhe, Yu, Yang, Wong, Frederick, Samuel, Koppara, Madiera, Maria, Karanam, Bindhu V., Reddy, Vijay B., Mitelman, Stan, Tong, Sharon X., Chicchi, Gary G., Tsao, Kwei-Lan, Trusca, Dorina, Feng, Yue, Wu, Margaret, Shao, Qing, Trujillo, Maria E., Eiermann, George J., Li, Cai, Pachanski, Michele, Fernandez, Guillermo, Nelson, Donald, Bunting, Patricia, Morissette, Pierre, Volksdorf, Sylvia, Kerr, Janet, Zhang, Bei B., Howard, Andrew D., Zhou, Yun-Ping, Pasternak, Alexander, Nargund, Ravi P., Hagmann, William K.
Gepubliceerd in ACS Med Chem Lett (2015)