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Investigation of Cardiovascular Effects of Tetrahydro-β-carboline sstr3 antagonists
[Image: see text] Antagonism of somatostatin subtype receptor 3 (sstr3) has emerged as a potential treatment of Type 2 diabetes. Unfortunately, the development of our first preclinical candidate, MK-4256, was discontinued due to a dose-dependent QTc (QT interval corrected for heart rate) prolongatio...
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Chemical
Society
2014
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Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4094257/ https://ncbi.nlm.nih.gov/pubmed/25050159 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500028c |
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