PPARγ and PPARδ negatively regulate specific subsets of lipopolysaccharide and IFN-γ target genes in macrophages

Por Welch, John S., Ricote, Mercedes, Akiyama, Taro E., Gonzalez, Frank J., Glass, Christopher K.
Publicado em 2003

Activation of peroxisome proliferator-activated receptor γ (PPARγ) by nitroalkene fatty acids: importance of nitration position and degree of unsaturation

Por Gorczynski, Michael J., Smitherman, Pamela K., Akiyama, Taro E., Wood, Harold B., Berger, Joel P., King, S. Bruce, Morrow, Charles S.
Publicado em 2009

Effects of FXR in Foam-cell Formation and Atherosclerosis Development

Por Guo, Grace L., Santamarina-Fojo, Silvia, Akiyama, Taro E., Amar, Marcelo J.A., Paigen, Beverly J., Brewer, Bryan, Gonzalez, Frank J.
Publicado em 2006

Dual Roles for Lipolysis and Oxidation in Peroxisome Proliferation-Activator Receptor Responses to Electronegative Low Density Lipoprotein

Por Ziouzenkova, Ouliana, Asatryan, Liana, Sahady, Deanna, Orasanu, Gabriela, Perrey, Stephan, Cutak, Benjamin, Hassell, Tom, Akiyama, Taro E., Berger, Joel P., Sevanian, Alex, Plutzky, Jorge
Publicado no J Biol Chem (2003)

Conditional Disruption of the Peroxisome Proliferator-Activated Receptor γ Gene in Mice Results in Lowered Expression of ABCA1, ABCG1, and apoE in Macrophages and Reduced Cholester...

Por Akiyama, Taro E., Sakai, Shuichi, Lambert, Gilles, Nicol, Christopher J., Matsusue, Kimihiko, Pimprale, Satish, Lee, Ying-Hue, Ricote, Mercedes, Glass, Christopher K., Brewer, H. Bryan, Gonzalez, Frank J.
Publicado em 2002

Retinaldehyde represses adipogenesis and diet-induced obesity

Por Ziouzenkova, Ouliana, Orasanu, Gabriela, Sharlach, Molly, Akiyama, Taro E, Berger, Joel P, Viereck, Jason, Hamilton, James A, Tang, Guangwen, Dolnikowski, Gregory G, Vogel, Silke, Duester, Gregg, Plutzky, Jorge
Publicado em 2007

Effects of small interfering RNA-mediated hepatic glucagon receptor inhibition on lipid metabolism in db/db mice

Por Han, Seongah, Akiyama, Taro E., Previs, Stephen F., Herath, Kithsiri, Roddy, Thomas P., Jensen, Kristian K., Guan, Hong-Ping, Murphy, Beth A., McNamara, Lesley A., Shen, Xun, Strapps, Walter, Hubbard, Brian K., Pinto, Shirly, Li, Cai, Li, Jing
Publicado em 2013

Selective Small-Molecule Agonists of G Protein–Coupled Receptor 40 Promote Glucose-Dependent Insulin Secretion and Reduce Blood Glucose in Mice

Por Tan, Carina P., Feng, Yue, Zhou, Yun-Ping, Eiermann, George J., Petrov, Aleksandr, Zhou, Changyou, Lin, Songnian, Salituro, Gino, Meinke, Peter, Mosley, Ralph, Akiyama, Taro E., Einstein, Monica, Kumar, Sanjeev, Berger, Joel P., Mills, Sander G., Thornberry, Nancy A., Yang, Lihu, Howard, Andrew D.
Publicado em 2008

Discovery of Chromane Propionic Acid Analogues as Selective Agonists of GPR120 with in Vivo Activity in Rodents

Por Adams, Gregory L., Velazquez, Francisco, Jayne, Charles, Shah, Unmesh, Miao, Shouwu, Ashley, Eric R., Madeira, Maria, Akiyama, Taro E., Di Salvo, Jerry, Suzuki, Takao, Wang, Nengxue, Truong, Quang, Gilbert, Eric, Zhou, Dan, Verras, Andreas, Kirkland, Melissa, Pachanski, Michele, Powles, Maryann, Yin, Wu, Ujjainwalla, Feroze, Venkatraman, Srikanth, Edmondson, Scott D.
Publicado no ACS Med Chem Lett (2016)

Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells()

Por Engelstoft, Maja S., Park, Won-mee, Sakata, Ichiro, Kristensen, Line V., Husted, Anna Sofie, Osborne-Lawrence, Sherri, Piper, Paul K., Walker, Angela K., Pedersen, Maria H., Nøhr, Mark K., Pan, Jie, Sinz, Christopher J., Carrington, Paul E., Akiyama, Taro E., Jones, Robert M., Tang, Cong, Ahmed, Kashan, Offermanns, Stefan, Egerod, Kristoffer L., Zigman, Jeffrey M., Schwartz, Thue W.
Publicado em 2013

A Gpr120 Selective Agonist Improves Insulin Resistance and Chronic Inflammation

Por Oh, Da Young, Walenta, Evelyn, Akiyama, Taro E., Lagakos, William S., Lackey, Denise, Pessentheiner, Ariane R., Sasik, Roman, Hah, Nasun, Chi, Tyler J., Cox, Jason M., Powels, Mary Ann, Salvo, Jerry Di, Sinz, Christopher, Watkins, Steven M., Armando, Aaron M., Chung, Heekyung, Evans, Ronald M., Quehenberger, Oswald, McNelis, Joanne, Bogner-Strauss, Juliane G., Olefsky, Jerrold M.
Publicado em 2014

Design, Synthesis, and Evaluation of Novel and Selective G-protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists

Por Cox, Jason M., Chu, Hong D., Chelliah, Mariappan V., Debenham, John S., Eagen, Keith, Lan, Ping, Lombardo, Matthew, London, Clare, Plotkin, Michael A., Shah, Unmesh, Sun, Zhongxiang, Vaccaro, Henry M., Venkatraman, Srikanth, Suzuki, Takao, Wang, Nengxue, Ashley, Eric R., Crespo, Alejandro, Madeira, Maria, Leung, Dennis H., Alleyne, Candice, Ogawa, Aimie M., Souza, Sarah, Thomas-Fowlkes, Brande, Di Salvo, Jerry, Weinglass, Adam, Kirkland, Melissa, Pachanski, Michele, Powles, Mary Ann, Tozzo, Effie, Akiyama, Taro E., Ujjainwalla, Feroze, Tata, James R., Sinz, Christopher J.
Publicado no ACS Med Chem Lett (2016)

Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia

Por Yin, Wu, Carballo-Jane, Ester, McLaren, David G., Mendoza, Vivienne H., Gagen, Karen, Geoghagen, Neil S., McNamara, Lesley Ann, Gorski, Judith N., Eiermann, George J., Petrov, Aleksandr, Wolff, Michael, Tong, Xinchun, Wilsie, Larissa C., Akiyama, Taro E., Chen, Jing, Thankappan, Anil, Xue, Jiyan, Ping, Xiaoli, Andrews, Genevieve, Wickham, L. Alexandra, Gai, Cesaire L., Trinh, Tu, Kulick, Alison A., Donnelly, Marcie J., Voronin, Gregory O., Rosa, Ray, Cumiskey, Anne-Marie, Bekkari, Kavitha, Mitnaul, Lyndon J., Puig, Oscar, Chen, Fabian, Raubertas, Richard, Wong, Peggy H., Hansen, Barbara C., Koblan, Ken S., Roddy, Thomas P., Hubbard, Brian K, Strack, Alison M.
Publicado em 2012