Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension

Por Petrilli, Whitney L., Hoyt, Scott B., London, Clare, McMasters, Daniel, Verras, Andreas, Struthers, Mary, Cully, Doris, Wisniewski, Thomas, Ren, Ning, Bopp, Charlene, Sok, Andrea, Chen, Qing, Li, Ying, Tung, Elaine, Tang, Wei, Salituro, Gino, Knemeyer, Ian, Karanam, Bindhu, Clemas, Joseph, Zhou, Gaochao, Gibson, Jack, Shipley, Carrie Ann, MacNeil, Douglas J., Duffy, Ruth, Tata, James R., Ujjainwalla, Feroze, Ali, Amjad, Xiong, Yusheng
Publicado no ACS Med Chem Lett (2016)

Design, Synthesis, and Evaluation of Novel and Selective G-protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists

Por Cox, Jason M., Chu, Hong D., Chelliah, Mariappan V., Debenham, John S., Eagen, Keith, Lan, Ping, Lombardo, Matthew, London, Clare, Plotkin, Michael A., Shah, Unmesh, Sun, Zhongxiang, Vaccaro, Henry M., Venkatraman, Srikanth, Suzuki, Takao, Wang, Nengxue, Ashley, Eric R., Crespo, Alejandro, Madeira, Maria, Leung, Dennis H., Alleyne, Candice, Ogawa, Aimie M., Souza, Sarah, Thomas-Fowlkes, Brande, Di Salvo, Jerry, Weinglass, Adam, Kirkland, Melissa, Pachanski, Michele, Powles, Mary Ann, Tozzo, Effie, Akiyama, Taro E., Ujjainwalla, Feroze, Tata, James R., Sinz, Christopher J.
Publicado no ACS Med Chem Lett (2016)

Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys

Por Hoyt, Scott B., Petrilli, Whitney, London, Clare, Liang, Gui-Bai, Tata, Jim, Hu, Qingzhong, Yin, Lina, van Koppen, Chris J., Hartmann, Rolf W., Struthers, Mary, Wisniewski, Tom, Ren, Ning, Bopp, Charlene, Sok, Andrea, Cai, Tian-Quan, Stribling, Sloan, Pai, Lee-Yuh, Ma, Xiuying, Metzger, Joe, Verras, Andreas, McMasters, Daniel, Chen, Qing, Tung, Elaine, Tang, Wei, Salituro, Gino, Buist, Nicole, Clemas, Joe, Zhou, Gaochao, Gibson, Jack, Maxwell, Carrie Ann, Lassman, Mike, McLaughlin, Theresa, Castro-Perez, Jose, Szeto, Daphne, Forrest, Gail, Hajdu, Richard, Rosenbach, Mark, Xiong, Yusheng
Publicado no ACS Med Chem Lett (2015)

Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys

Por Hoyt, Scott B., Park, Min K., London, Clare, Xiong, Yusheng, Tata, Jim, Bennett, D. Jonathan, Cooke, Andrew, Cai, Jiaqiang, Carswell, Emma, Robinson, John, MacLean, John, Brown, Lindsay, Belshaw, Simone, Clarkson, Thomas R., Liu, Kun, Liang, Gui-Bai, Struthers, Mary, Cully, Doris, Wisniewski, Tom, Ren, Ning, Bopp, Charlene, Sok, Andrea, Cai, Tian-Quan, Stribling, Sloan, Pai, Lee-Yuh, Ma, Xiuying, Metzger, Joe, Verras, Andreas, McMasters, Daniel, Chen, Qing, Tung, Elaine, Tang, Wei, Salituro, Gino, Buist, Nicole, Kuethe, Jeff, Rivera, Nelo, Clemas, Joe, Zhou, Gaochao, Gibson, Jack, Maxwell, Carrie Ann, Lassman, Mike, McLaughlin, Theresa, Castro-Perez, Jose, Szeto, Daphne, Forrest, Gail, Hajdu, Richard, Rosenbach, Mark, Ali, Amjad
Publicado no ACS Med Chem Lett (2015)