Insights in 17β-HSD1 Enzyme Kinetics and Ligand Binding by Dynamic Motion Investigation

Por Negri, Matthias, Recanatini, Maurizio, Hartmann, Rolf W.
Publicado em 2010

3-Pyridyl Substituted Aliphatic Cycles as CYP11B2 Inhibitors: Aromaticity Abolishment of the Core Significantly Increased Selectivity over CYP1A2

Por Yin, Lina, Hu, Qingzhong, Hartmann, Rolf W.
Publicado em 2012

Recent Progress in Pharmaceutical Therapies for Castration-Resistant Prostate Cancer

Por Yin, Lina, Hu, Qingzhong, Hartmann, Rolf W.
Publicado em 2013

Crystal structure of 4-methyl­sulfanyl-2-(2H-tetra­zol-2-yl)pyrimidine

Por Thomann, Andreas, Huch, Volker, Hartmann, Rolf W.
Publicado no Acta Crystallogr E Crystallogr Commun (2015)

Rule–based regulatory and metabolic model for Quorum sensing in P. aeruginosa

Por Schaadt, Nadine S, Steinbach, Anke, Hartmann, Rolf W, Helms, Volkhard
Publicado em 2013

Optimization of the First Selective Steroid-11β-hydroxylase (CYP11B1) Inhibitors for the Treatment of Cortisol Dependent Diseases

Por Hille, Ulrike E., Zimmer, Christina, Haupenthal, Jörg, Hartmann, Rolf W.
Publicado em 2011

First Selective CYP11B1 Inhibitors for the Treatment of Cortisol-Dependent Diseases

Por Hille, Ulrike E., Zimmer, Christina, Vock, Carsten A., Hartmann, Rolf W.
Publicado em 2010

New Insights into the Bacterial RNA Polymerase Inhibitor CBR703 as a Starting Point for Optimization as an Anti-Infective Agent

Por Zhu, Weixing, Haupenthal, Jörg, Groh, Matthias, Fountain, Michelle, Hartmann, Rolf W.
Publicado em 2014

Hydroxybenzothiophene Ketones Are Efficient Pre-mRNA Splicing Modulators Due to Dual Inhibition of Dyrk1A and Clk1/4

Por Schmitt, Christian, Miralinaghi, Parisa, Mariano, Marica, Hartmann, Rolf W., Engel, Matthias
Publicado em 2014

Microwave-Assisted Syntheses of Amino Acid Ester Substituted Benzoic Acid Amides: Potential Inhibitors of Human CD81-Receptor HCV-E2 Interaction

Por Holzer, Marcel, Ziegler, Sigrid, Kronenberger, Bernd, Klein, Christian D, Hartmann, Rolf W
Publicado em 2008

Influence of DNA Template Choice on Transcription and Inhibition of Escherichia coli RNA Polymerase

Por Haupenthal, Joerg, Hüsecken, Kristina, Negri, Matthias, Maurer, Christine K., Hartmann, Rolf W.
Publicado em 2012

Molecular basis of HHQ biosynthesis: molecular dynamics simulations, enzyme kinetic and surface plasmon resonance studies

Por Steinbach, Anke, Maurer, Christine K, Weidel, Elisabeth, Henn, Claudia, Brengel, Christian, Hartmann, Rolf W, Negri, Matthias
Publicado em 2013

Design and Synthesis of a Library of Lead-Like 2,4-Bisheterocyclic Substituted Thiophenes as Selective Dyrk/Clk Inhibitors

Por Schmitt, Christian, Kail, Dagmar, Mariano, Marica, Empting, Martin, Weber, Nadja, Paul, Tamara, Hartmann, Rolf W., Engel, Matthias
Publicado em 2014

Design of Novel β-Carboline Derivatives with Pendant 5-Bromothienyl and Their Evaluation as Phosphodiesterase-5 Inhibitors

Por El-Gamil, Dalia S., Ahmed, Nermin S., Gary, Bernard D., Piazza, Gary A., Engel, Matthias, Hartmann, Rolf W., Abadi, Ashraf H.
Publicado no Arch Pharm (Weinheim) (2013)

17β-Hydroxysteroid Dehydrogenase Type 2 Inhibition: Discovery of Selective and Metabolically Stable Compounds Inhibiting Both the Human Enzyme and Its Murine Ortholog

Por Gargano, Emanuele M., Allegretta, Giuseppe, Perspicace, Enrico, Carotti, Angelo, Van Koppen, Chris, Frotscher, Martin, Marchais-Oberwinkler, Sandrine, Hartmann, Rolf W.
Publicado no PLoS One (2015)

The IGF2 mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis

Por Laggai, Stephan, Kessler, Sonja M., Boettcher, Stefan, Lebrun, Valérie, Gemperlein, Katja, Lederer, Eva, Leclercq, Isabelle A., Mueller, Rolf, Hartmann, Rolf W., Haybaeck, Johannes, Kiemer, Alexandra K.
Publicado em 2014

Allosteric activation of the protein kinase PDK1 with low molecular weight compounds

Por Engel, Matthias, Hindie, Valerie, Lopez-Garcia, Laura A, Stroba, Adriana, Schaeffer, Francis, Adrian, Iris, Imig, Jochen, Idrissova, Leila, Nastainczyk, Wolfgang, Zeuzem, Stefan, Alzari, Pedro M, Hartmann, Rolf W, Piiper, Albrecht, Biondi, Ricardo M
Publicado em 2006

Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys

Por Hoyt, Scott B., Petrilli, Whitney, London, Clare, Liang, Gui-Bai, Tata, Jim, Hu, Qingzhong, Yin, Lina, van Koppen, Chris J., Hartmann, Rolf W., Struthers, Mary, Wisniewski, Tom, Ren, Ning, Bopp, Charlene, Sok, Andrea, Cai, Tian-Quan, Stribling, Sloan, Pai, Lee-Yuh, Ma, Xiuying, Metzger, Joe, Verras, Andreas, McMasters, Daniel, Chen, Qing, Tung, Elaine, Tang, Wei, Salituro, Gino, Buist, Nicole, Clemas, Joe, Zhou, Gaochao, Gibson, Jack, Maxwell, Carrie Ann, Lassman, Mike, McLaughlin, Theresa, Castro-Perez, Jose, Szeto, Daphne, Forrest, Gail, Hajdu, Richard, Rosenbach, Mark, Xiong, Yusheng
Publicado no ACS Med Chem Lett (2015)