Allosteric activation of the protein kinase PDK1 with low molecular weight compounds

Organisms rely heavily on protein phosphorylation to transduce intracellular signals. The phosphorylation of a protein often induces conformational changes, which are responsible for triggering downstream cellular events. Protein kinases are themselves frequently regulated by phosphorylation. Recent...

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Main Authors: Engel, Matthias, Hindie, Valerie, Lopez-Garcia, Laura A, Stroba, Adriana, Schaeffer, Francis, Adrian, Iris, Imig, Jochen, Idrissova, Leila, Nastainczyk, Wolfgang, Zeuzem, Stefan, Alzari, Pedro M, Hartmann, Rolf W, Piiper, Albrecht, Biondi, Ricardo M
格式: Artigo
語言:Inglês
出版: 2006
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1679772/
https://ncbi.nlm.nih.gov/pubmed/17110931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601416
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