Insights in 17β-HSD1 Enzyme Kinetics and Ligand Binding by Dynamic Motion Investigation

por Negri, Matthias, Recanatini, Maurizio, Hartmann, Rolf W.
Publicado 2010

3-Pyridyl Substituted Aliphatic Cycles as CYP11B2 Inhibitors: Aromaticity Abolishment of the Core Significantly Increased Selectivity over CYP1A2

por Yin, Lina, Hu, Qingzhong, Hartmann, Rolf W.
Publicado 2012

Recent Progress in Pharmaceutical Therapies for Castration-Resistant Prostate Cancer

por Yin, Lina, Hu, Qingzhong, Hartmann, Rolf W.
Publicado 2013

Crystal structure of 4-methyl­sulfanyl-2-(2H-tetra­zol-2-yl)pyrimidine

por Thomann, Andreas, Huch, Volker, Hartmann, Rolf W.
Publicado en Acta Crystallogr E Crystallogr Commun (2015)

Synthesis and Biological Evaluation of Thieno[3,2-d]- pyrimidinones, Thieno[3,2-d]pyrimidines and Quinazolinones: Conformationally Restricted 17β-Hydroxysteroid Dehydrogenase Type...

por Perspicace, Enrico, Marchais-Oberwinkler, Sandrine, Hartmann, Rolf W.
Publicado en Molecules (2013)

Rule–based regulatory and metabolic model for Quorum sensing in P. aeruginosa

por Schaadt, Nadine S, Steinbach, Anke, Hartmann, Rolf W, Helms, Volkhard
Publicado 2013

Optimization of the First Selective Steroid-11β-hydroxylase (CYP11B1) Inhibitors for the Treatment of Cortisol Dependent Diseases

por Hille, Ulrike E., Zimmer, Christina, Haupenthal, Jörg, Hartmann, Rolf W.
Publicado 2011

First Selective CYP11B1 Inhibitors for the Treatment of Cortisol-Dependent Diseases

por Hille, Ulrike E., Zimmer, Christina, Vock, Carsten A., Hartmann, Rolf W.
Publicado 2010

New Insights into the Bacterial RNA Polymerase Inhibitor CBR703 as a Starting Point for Optimization as an Anti-Infective Agent

por Zhu, Weixing, Haupenthal, Jörg, Groh, Matthias, Fountain, Michelle, Hartmann, Rolf W.
Publicado 2014

Hydroxybenzothiophene Ketones Are Efficient Pre-mRNA Splicing Modulators Due to Dual Inhibition of Dyrk1A and Clk1/4

por Schmitt, Christian, Miralinaghi, Parisa, Mariano, Marica, Hartmann, Rolf W., Engel, Matthias
Publicado 2014

Pharmacophore Modeling and in Silico/in Vitro Screening for Human Cytochrome P450 11B1 and Cytochrome P450 11B2 Inhibitors

por Akram, Muhammad, Waratchareeyakul, Watcharee, Haupenthal, Joerg, Hartmann, Rolf W., Schuster, Daniela
Publicado en Front Chem (2017)

Microwave-Assisted Syntheses of Amino Acid Ester Substituted Benzoic Acid Amides: Potential Inhibitors of Human CD81-Receptor HCV-E2 Interaction

por Holzer, Marcel, Ziegler, Sigrid, Kronenberger, Bernd, Klein, Christian D, Hartmann, Rolf W
Publicado 2008

Influence of DNA Template Choice on Transcription and Inhibition of Escherichia coli RNA Polymerase

por Haupenthal, Joerg, Hüsecken, Kristina, Negri, Matthias, Maurer, Christine K., Hartmann, Rolf W.
Publicado 2012

Molecular basis of HHQ biosynthesis: molecular dynamics simulations, enzyme kinetic and surface plasmon resonance studies

por Steinbach, Anke, Maurer, Christine K, Weidel, Elisabeth, Henn, Claudia, Brengel, Christian, Hartmann, Rolf W, Negri, Matthias
Publicado 2013

In-depth Profiling of MvfR-Regulated Small Molecules in Pseudomonas aeruginosa after Quorum Sensing Inhibitor Treatment

por Allegretta, Giuseppe, Maurer, Christine K., Eberhard, Jens, Maura, Damien, Hartmann, Rolf W., Rahme, Laurence, Empting, Martin
Publicado en Front Microbiol (2017)

Design and Synthesis of a Library of Lead-Like 2,4-Bisheterocyclic Substituted Thiophenes as Selective Dyrk/Clk Inhibitors

por Schmitt, Christian, Kail, Dagmar, Mariano, Marica, Empting, Martin, Weber, Nadja, Paul, Tamara, Hartmann, Rolf W., Engel, Matthias
Publicado 2014

Design of Novel β-Carboline Derivatives with Pendant 5-Bromothienyl and Their Evaluation as Phosphodiesterase-5 Inhibitors

por El-Gamil, Dalia S., Ahmed, Nermin S., Gary, Bernard D., Piazza, Gary A., Engel, Matthias, Hartmann, Rolf W., Abadi, Ashraf H.
Publicado en Arch Pharm (Weinheim) (2013)

17β-Hydroxysteroid Dehydrogenase Type 2 Inhibition: Discovery of Selective and Metabolically Stable Compounds Inhibiting Both the Human Enzyme and Its Murine Ortholog

por Gargano, Emanuele M., Allegretta, Giuseppe, Perspicace, Enrico, Carotti, Angelo, Van Koppen, Chris, Frotscher, Martin, Marchais-Oberwinkler, Sandrine, Hartmann, Rolf W.
Publicado en PLoS One (2015)

Identification of Terfenadine as an Inhibitor of HumanCD81-Receptor HCV-E2 Interaction: Synthesis and Structure Optimization

por Holzer, Marcel, Ziegler, Sigrid, Albrecht, Beatrice, Kronenberger, Bernd, Kaul, Artur, Bartenschlager, Ralf, Kattner, Lars, Klein, Christian D., Hartmann, Rolf W.
Publicado en Molecules (2008)

Phosphonate as a Stable Zinc‐Binding Group for “Pathoblocker” Inhibitors of Clostridial Collagenase H (ColH)

por Voos, Katrin, Schönauer, Esther, Alhayek, Alaa, Haupenthal, Jörg, Andreas, Anastasia, Müller, Rolf, Hartmann, Rolf W., Brandstetter, Hans, Hirsch, Anna K. H., Ducho, Christian
Publicado en ChemMedChem (2021)