Design and synthesis of novel 1,3,5-triphenyl pyrazolines as potential anti-inflammatory agents through allosteric inhibition of protein kinase Czeta (PKCζ)

di Abdel-Halim, Mohammad, Abadi, Ashraf H., Engel, Matthias
Pubblicato in Medchemcomm (2018)

Synthesis, Molecular Modeling, and Biological Evaluation of Novel Tetrahydro-β-Carboline Hydantoin and Tetrahydro-β-Carboline Thiohydantoin Derivatives as Phosphodiesterase 5 Inhib...

di Abadi, Ashraf H., Lehmann, Jochen, Piazza, Gary A., Abdel-Halim, Mohammad, Ali, Mohamed S. M.
Pubblicato in Int J Med Chem (2011)

Synthesis, molecular modeling and biological evaluation of novel tadalafil analogues as phosphodiesterase 5 and colon tumor cell growth inhibitors, new stereochemical perspective

di Abadi, Ashraf H., Gary, Bernard D., Tinsley, Heather N., Piazza, Gary A., Abdel-Halim, Mohammad
Pubblicato in Eur J Med Chem (2010)

A Novel Access to Arylated and Heteroarylated Beta-Carboline Based PDE5 Inhibitors

di Ahmed, Nermin S., Gary, Bernard D., Piazza, Gary A., Tinsley, Heather N., Laufer, Stefan, Abadi, Ashraf H.
Pubblicato in Med Chem (2010)

Design, Synthesis and Structure–Activity Relationship of Functionalized Tetrahydro-β-carboline Derivatives as Novel PDE5 Inhibitors

di Ahmed, Nermin S., Gary, Bernard D., Tinsley, Hethar N., Piazza, Gary A., Laufer, Stefan, Abadi, Ashraf H.
Pubblicato in Arch Pharm (Weinheim) (2010)

Design of Novel β-Carboline Derivatives with Pendant 5-Bromothienyl and Their Evaluation as Phosphodiesterase-5 Inhibitors

di El-Gamil, Dalia S., Ahmed, Nermin S., Gary, Bernard D., Piazza, Gary A., Engel, Matthias, Hartmann, Rolf W., Abadi, Ashraf H.
Pubblicato in Arch Pharm (Weinheim) (2013)

Structure-Based Design of Novel Tetrahydro-Beta-Carboline Derivatives with a Hydrophilic Side Chain as Potential Phosphodiesterase Inhibitors

di Elhady, Ahmed K., Sigler, Sara C., Noureldin, Nazih, Canzoneri, Joshua C., Ahmed, Nermin S., Piazza, Gary A., Abadi, Ashraf H.
Pubblicato in Sci Pharm (2015)

Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by PDE5 inhibition, elevation of cGMP, and activation of PKG

di Tinsley, Heather N., Gary, Bernard D., Keeton, Adam B., Zhang, Wei, Abadi, Ashraf H., Reynolds, Robert C., Piazza, Gary A.
Pubblicazione 2009

Design, synthesis and biological evaluation of novel pyridine derivatives as anticancer agents and phosphodiesterase 3 inhibitors

di Abadi, Ashraf H., Ibrahim, Tamer M., Abouzid, Khaled M., Lehmann, Jochen, Tinsley, Heather N., Gary, Bernard D., Piazza, Gary A.
Pubblicato in Bioorg Med Chem (2009)

Design and Synthesis of Novel Symmetric Fluorene-2,7-Diamine Derivatives as Potent Hepatitis C Virus Inhibitors

di Mousa, Mai H. A., Ahmed, Nermin S., Schwedtmann, Kai, Frakolaki, Efseveia, Vassilaki, Niki, Zoidis, Grigoris, Weigand, Jan J., Abadi, Ashraf H.
Pubblicato in Pharmaceuticals (Basel) (2021)

Symmetric Anti-HCV Agents: Synthesis, Antiviral Properties, and Conformational Aspects of Core Scaffolds

di Leila, Alaa R. S., Mousa, Mai H. A., Frakolaki, Efseveia, Vassilaki, Niki, Bartenschlager, Ralf, Zoidis, Grigoris, Abdel-Halim, Mohammad, Abadi, Ashraf H.
Pubblicato in ACS Omega (2019)

5-Methoxybenzothiophene-2-Carboxamides as Inhibitors of Clk1/4: Optimization of Selectivity and Cellular Potency

di ElHady, Ahmed K., El-Gamil, Dalia S., Chen, Po-Jen, Hwang, Tsong-Long, Abadi, Ashraf H., Abdel-Halim, Mohammad, Engel, Matthias
Pubblicato in Molecules (2021)

Synthesis of Novel Tadalafil Analogues and their Evaluation as Phosphodiesterase Inhibitors and Anticancer Agents

di Abadi, Ashraf H., Abouel-Ella, Dalal A., Ahmed, Nermin S., Gary, Bernard D., Thaiparambil, Jose T., Tinsley, Heather N., Keeton, Adam B., Piazza, Gary A.
Pubblicato in Arzneimittelforschung (2009)

Four-Component Synthesis of 1,2-Dihydropyridine Derivatives and their Evaluation as Anticancer Agents

di Abdelf-Fattah, Mohamed A. O., El-Naggar, Mahmoud A. M., Rashied, Rasha M. H., Gary, Bernard D., Piazza, Gary A., Abadi, Ashraf H.
Pubblicato in Med Chem (2012)

Discovery of colon tumor cell growth inhibitory agents through a combinatorial approach

di Abadi, Ashraf H., Abouel-Ella, Dalal A., Lehmann, Jochen, Tinsley, Heather N., Gary, Bernard D., Piazza, Gary A., Abdel-Fattah, Mohammed A.O.
Pubblicato in Eur J Med Chem (2009)

Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives

di Ahmed, Nermin S., Ali, Amal H., El-Nashar, Shreen M., Gary, Bernard D., Fajardo, Alexandra M., Tinsley, Heather N., Piazza, Gary A., Negri, Matthias, Abadi, Ashraf H.
Pubblicato in Eur J Med Chem (2012)

Synthesis and Molecular Modeling of Novel Tetrahydro-β-carboline Derivatives with Phosphodiesterase 5 Inhibitory and Anticancer Properties

di Mohamed, Heba A., Girgis, Nancy M. R., Wilcken, Rainer, Bauer, Matthias R., Tinsley, Heather N., Gary, Bernard D., Piazza, Gary A., Boeckler, Frank M., Abadi, Ashraf H.
Pubblicato in J Med Chem (2010)

CoMFA and CoMSIA Studies of 1,2-dihydropyridine Derivatives as Anticancer Agents

di Salama, Ismail, Abdel-Fattah, Mohamed A. O., Hany, Marwa S., El-Sharif, Shaimaa A., El-Naggar, Mahmoud A. M., Rashied, Rasha M. H., Piazza, Gary A., Abadi, Ashraf H.
Pubblicato in Med Chem (2012)

Discovery of trisubstituted pyrazolines as a novel scaffold for the development of selective phosphodiesterase 5 inhibitors

di Abdel-Halim, Mohammad, Tinsley, Heather, Keeton, Adam B., Weam, Mohammed, Atta, Noha H., Hammam, Mennatallah A., Hefnawy, Amr, Hartmann, Rolf W., Engel, Matthias, Piazza, Gary A., Abadi, Ashraf H.
Pubblicato in Bioorg Chem (2020)

A Novel Sulindac Derivative that Potently Suppresses Colon Tumor Cell Growth by Inhibiting cGMP Phosphodiesterase and β-Catenin Transcriptional Activity

di Whitt, Jason D., Li, Nan, Tinsley, Heather N., Chen, Xi, Zhang, Wei, Li, Yonghe, Gary, Bernard D., Keeton, Adam B., Xi, Yaguang, Abadi, Ashraf H., Grizzle, William E., Piazza, Gary A.
Pubblicazione 2012