Structure-Based Design of Novel Tetrahydro-Beta-Carboline Derivatives with a Hydrophilic Side Chain as Potential Phosphodiesterase Inhibitors

Tadalafil is a clinically approved phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction and pulmonary arterial hypertension. It contains two chiral carbons, and the marketed isomer is the 6R, 12aR isomer with a methyl substituent on the terminal nitrogen of the piperazinedione rin...

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Veröffentlicht in:Sci Pharm
Hauptverfasser: Elhady, Ahmed K., Sigler, Sara C., Noureldin, Nazih, Canzoneri, Joshua C., Ahmed, Nermin S., Piazza, Gary A., Abadi, Ashraf H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064235/
https://ncbi.nlm.nih.gov/pubmed/28117310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/scipharm84030428
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