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Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by PDE5 inhibition, elevation of cGMP, and activation of PKG

Sulindac displays promising antineoplastic activity, but toxicities from cyclooxygenase (COX) inhibition limit its use for chemoprevention. Previous reports suggest that its anticancer properties may be attributed to a COX-independent mechanism, although alternative targets have not been well define...

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Bibliografiske detaljer
Main Authors: Tinsley, Heather N., Gary, Bernard D., Keeton, Adam B., Zhang, Wei, Abadi, Ashraf H., Reynolds, Robert C., Piazza, Gary A.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805153/
https://ncbi.nlm.nih.gov/pubmed/19996273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0758
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