Sulindac selectively inhibits colon tumor cell growth by activating the cGMP/PKG pathway to suppress Wnt/β-catenin signaling

NSAIDs display promising antineoplastic activity for colorectal and other cancers, but toxicity from cyclooxygenase (COX) inhibition limits their long-term use for chemoprevention. Previous studies have concluded that the basis for their tumor cell growth inhibitory activity does not required COX in...

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Detalhes bibliográficos
Main Authors: Li, Nan, Xi, Yaguang, Tinsley, Heather N., Gurpinar, Evrim, Gary, Bernard D., Zhu, Bing, Li, Yonghe, Chen, Xi, Keeton, Adam B., Abadi, Ashraf H., Moyer, Mary P., Grizzle, William E., Chang, Wen-chi, Clapper, Margie L., Piazza, Gary A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3800150/
https://ncbi.nlm.nih.gov/pubmed/23804703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-13-0048
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