PDE5 and PDE10 inhibition activates cGMP/PKG signaling to block Wnt/β-catenin transcription, cancer cell growth, and tumor immunity

Although numerous reports conclude that nonsteroidal anti-inflammatory drugs (NSAIDs) have anticancer activity, this common drug class is not recommended for long-term use because of potentially fatal toxicities from cyclooxygenase (COX) inhibition. Studies suggest the mechanism responsible for the...

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Detalhes bibliográficos
Publicado no:Drug Discov Today
Main Authors: Piazza, Gary A., Ward, Antonio, Chen, Xi, Maxuitenko, Yulia, Coley, Alex, Aboelella, Nada S., Buchsbaum, Donald J., Boyd, Michael R., Keeton, Adam B., Zhou, Gang
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484431/
https://ncbi.nlm.nih.gov/pubmed/32562844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2020.06.008
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