β-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A inhibition, cGMP elevation, and activation of PKG

Phosphodiesterase 10A (PDE10) is a cGMP and cAMP degrading PDE isozyme that is highly expressed in the brain striatum where it appears to play an important role in cognition and psychomotor activity. PDE10 inhibitors are being developed for the treatment of schizophrenia and Huntington's diseas...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lee, Kevin, Lindsey, Ashley S., Li, Nan, Gary, Bernard, Andrews, Joel, Keeton, Adam B., Piazza, Gary A.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4868691/
https://ncbi.nlm.nih.gov/pubmed/26713600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.6705
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