Individual Cerebellar Purkinje Cells Express Different cGMP Phosphodiesterases (PDEs): In Vivo Phosphorylation of cGMP-Specific PDE (PDE5) as an Indicator of cGMP-dependent protein kinase (PKG) Activation

The nitric oxide (NO)-cGMP pathway has been implicated as playing a crucial role in the induction of cerebellar long-term depression (LTD). The amplitude and duration of the cGMP signal is controlled by cyclic nucleotide phosphodiesterases (PDEs). Here we identify PDE5 and PDE1B as the two major cGM...

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Détails bibliographiques
Publié dans:J Neurosci
Auteurs principaux: Shimizu-Albergine, Masami, Rybalkin, Sergei D., Rybalkina, Irina G., Feil, Robert, Wolfsgruber, Wiebke, Hofmann, Franz, Beavo, Joseph A.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2003
Sujets:
Cellular/Molecular
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740622/
https://ncbi.nlm.nih.gov/pubmed/12878685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-16-06452.2003
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