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PDE5 and PDE10 inhibition activates cGMP/PKG signaling to block Wnt/β-catenin transcription, cancer cell growth, and tumor immunity

Although numerous reports conclude that nonsteroidal anti-inflammatory drugs (NSAIDs) have anticancer activity, this common drug class is not recommended for long-term use because of potentially fatal toxicities from cyclooxygenase (COX) inhibition. Studies suggest the mechanism responsible for the...

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מידע ביבליוגרפי
הוצא לאור ב:	Drug Discov Today
Main Authors:	Piazza, Gary A., Ward, Antonio, Chen, Xi, Maxuitenko, Yulia, Coley, Alex, Aboelella, Nada S., Buchsbaum, Donald J., Boyd, Michael R., Keeton, Adam B., Zhou, Gang
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	2020
נושאים:	Article
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7484431/ https://ncbi.nlm.nih.gov/pubmed/32562844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2020.06.008
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!

PDE5 and PDE10 inhibition activates cGMP/PKG signaling to block Wnt/β-catenin transcription, cancer cell growth, and tumor immunity

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