A Novel Sulindac Derivative that Potently Suppresses Colon Tumor Cell Growth by Inhibiting cGMP Phosphodiesterase and β-Catenin Transcriptional Activity

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been widely reported to inhibit tumor growth by a COX-independent mechanism, although alternative targets have not been well defined or used to develop improved drugs for cancer chemoprevention. Here, we characterize a novel sulindac derivative refe...

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Detalhes bibliográficos
Main Authors: Whitt, Jason D., Li, Nan, Tinsley, Heather N., Chen, Xi, Zhang, Wei, Li, Yonghe, Gary, Bernard D., Keeton, Adam B., Xi, Yaguang, Abadi, Ashraf H., Grizzle, William E., Piazza, Gary A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3546530/
https://ncbi.nlm.nih.gov/pubmed/22556201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-11-0559
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