cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action

To date, studies suggest that biological signaling by nitric oxide (NO) is primarily mediated by cGMP, which is synthesized by NO-activated guanylyl cyclases and broken down by cyclic nucleotide phosphodiesterases (PDEs). Effects of cGMP occur through three main groups of cellular targets: cGMP-depe...

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Bibliographic Details
Main Authors: Francis, Sharron H., Busch, Jennifer L., Corbin, Jackie D.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2010
Subjects:
Review Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2964902/
https://ncbi.nlm.nih.gov/pubmed/20716671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/pr.110.002907
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