Colon tumor cell growth inhibitory activity of sulindac sulfide and other NSAIDs is associated with PDE5 inhibition

In experimental studies, nonsteroidal anti-inflammatory drugs (NSAIDs) display promising antineoplastic activity, but toxicity resulting from cyclooxygenase (COX) inhibition limits their clinical use for chemoprevention. Studies suggest that the mechanism may be COX independent, although alternative...

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Detalhes bibliográficos
Main Authors: Tinsley, Heather N., Gary, Bernard D., Thaiparambil, Jose, Li, Nan, Lu, Wenyan, Li, Yonghe, Maxuitenko, Yulia Y., Keeton, Adam B., Piazza, Gary A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955813/
https://ncbi.nlm.nih.gov/pubmed/20876730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-10-0030
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