A Novel Sulindac Derivative That Does Not Inhibit Cyclooxygenases but Potently Inhibits Colon Tumor Cell Growth and Induces Apoptosis with Antitumor Activity

Nonsteroidal anti-inflammatory drugs such as sulindac have shown promising antineoplastic activity, although toxicity from cyclooxygenase (COX) inhibition and the suppression of prostaglandin synthesis limits their use for chemoprevention. Previous studies have concluded that the mechanism responsib...

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Hlavní autoři: Piazza, Gary A., Keeton, Adam B., Tinsley, Heather N., Gary, Bernard D., Whitt, Jason D., Mathew, Bini, Thaiparambil, Jose, Coward, Lori, Gorman, Gregory, Li, Yonghe, Sani, Brahma, Hobrath, Judith V., Maxuitenko, Yulia Y., Reynolds, Robert C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227417/
https://ncbi.nlm.nih.gov/pubmed/19470791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-09-0001
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