A Novel Sulindac Derivative That Does Not Inhibit Cyclooxygenases but Potently Inhibits Colon Tumor Cell Growth and Induces Apoptosis with Antitumor Activity

Nonsteroidal anti-inflammatory drugs such as sulindac have shown promising antineoplastic activity, although toxicity from cyclooxygenase (COX) inhibition and the suppression of prostaglandin synthesis limits their use for chemoprevention. Previous studies have concluded that the mechanism responsib...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Piazza, Gary A., Keeton, Adam B., Tinsley, Heather N., Gary, Bernard D., Whitt, Jason D., Mathew, Bini, Thaiparambil, Jose, Coward, Lori, Gorman, Gregory, Li, Yonghe, Sani, Brahma, Hobrath, Judith V., Maxuitenko, Yulia Y., Reynolds, Robert C.
التنسيق: Artigo
اللغة:Inglês
منشور في: 2009
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227417/
https://ncbi.nlm.nih.gov/pubmed/19470791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-09-0001
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