A Novel Sulindac Derivative That Does Not Inhibit Cyclooxygenases but Potently Inhibits Colon Tumor Cell Growth and Induces Apoptosis with Antitumor Activity

Nonsteroidal anti-inflammatory drugs such as sulindac have shown promising antineoplastic activity, although toxicity from cyclooxygenase (COX) inhibition and the suppression of prostaglandin synthesis limits their use for chemoprevention. Previous studies have concluded that the mechanism responsib...

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Detalhes bibliográficos
Main Authors: Piazza, Gary A., Keeton, Adam B., Tinsley, Heather N., Gary, Bernard D., Whitt, Jason D., Mathew, Bini, Thaiparambil, Jose, Coward, Lori, Gorman, Gregory, Li, Yonghe, Sani, Brahma, Hobrath, Judith V., Maxuitenko, Yulia Y., Reynolds, Robert C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227417/
https://ncbi.nlm.nih.gov/pubmed/19470791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-09-0001
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