Colon tumor cell growth inhibitory activity of sulindac sulfide and other NSAIDs is associated with PDE5 inhibition

In experimental studies, nonsteroidal anti-inflammatory drugs (NSAIDs) display promising antineoplastic activity, but toxicity resulting from cyclooxygenase (COX) inhibition limits their clinical use for chemoprevention. Studies suggest that the mechanism may be COX independent, although alternative...

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Hauptverfasser: Tinsley, Heather N., Gary, Bernard D., Thaiparambil, Jose, Li, Nan, Lu, Wenyan, Li, Yonghe, Maxuitenko, Yulia Y., Keeton, Adam B., Piazza, Gary A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2955813/
https://ncbi.nlm.nih.gov/pubmed/20876730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-10-0030
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