Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by PDE5 inhibition, elevation of cGMP, and activation of PKG

Sulindac displays promising antineoplastic activity, but toxicities from cyclooxygenase (COX) inhibition limit its use for chemoprevention. Previous reports suggest that its anticancer properties may be attributed to a COX-independent mechanism, although alternative targets have not been well define...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Tinsley, Heather N., Gary, Bernard D., Keeton, Adam B., Zhang, Wei, Abadi, Ashraf H., Reynolds, Robert C., Piazza, Gary A.
Format: Artigo
Langue:Inglês
Publié: 2009
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805153/
https://ncbi.nlm.nih.gov/pubmed/19996273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0758
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires