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Exploring the PDE5 H-pocket by ensemble docking and structure-based design and synthesis of novel β-carboline derivatives

By studying the co-crystal information of interactions between PDE5 and its inhibitors, forty new tetrahydro-β-carbolines based-analogues were synthesized, and tested for their PDE5 inhibition. Some compounds were as active as tadalafil in inhibiting PDE5 and of better selectivity profile particular...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Ahmed, Nermin S., Ali, Amal H., El-Nashar, Shreen M., Gary, Bernard D., Fajardo, Alexandra M., Tinsley, Heather N., Piazza, Gary A., Negri, Matthias, Abadi, Ashraf H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4994520/
https://ncbi.nlm.nih.gov/pubmed/23117589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2012.09.029
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