Synthesis of Novel Tadalafil Analogues and their Evaluation as Phosphodiesterase Inhibitors and Anticancer Agents

Two closely related series of novel β-carboline derivatives, electronically similar to tadalafil (CAS 171596-29-5), were synthesized and evaluated for their inhibitory effects upon phosphodiesterase 5 (PDE5) and phosphodiesterase 11 (PDE11) and their in vitro tumor cell growth inhibitory activity ve...

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Publicado no:Arzneimittelforschung
Main Authors: Abadi, Ashraf H., Abouel-Ella, Dalal A., Ahmed, Nermin S., Gary, Bernard D., Thaiparambil, Jose T., Tinsley, Heather N., Keeton, Adam B., Piazza, Gary A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4980831/
https://ncbi.nlm.nih.gov/pubmed/19813465
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