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Insights in 17β-HSD1 Enzyme Kinetics and Ligand Binding by Dynamic Motion Investigation
BACKGROUND: Bisubstrate enzymes, such as 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1), exist in solution as an ensemble of conformations. 17β-HSD1 catalyzes the last step of the biosynthesis of estradiol and, thus, it is a potentially attractive target for breast cancer treatment. METHODOLOGY/...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2919385/ https://ncbi.nlm.nih.gov/pubmed/20706575 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012026 |
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