Mutations in the MutSα interaction interface of MLH1 can abolish DNA mismatch repair

MutLα, a heterodimer of MLH1 and PMS2, plays a central role in human DNA mismatch repair. It interacts ATP-dependently with the mismatch detector MutSα and assembles and controls further repair enzymes. We tested if the interaction of MutLα with DNA-bound MutSα is impaired by cancer-associated mutat...

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Detalhes bibliográficos
Main Authors: Plotz, Guido, Welsch, Christoph, Giron-Monzon, Luis, Friedhoff, Peter, Albrecht, Mario, Piiper, Albrecht, Biondi, Ricardo M., Lengauer, Thomas, Zeuzem, Stefan, Raedle, Jochen
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2006
Assuntos:
Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1747184/
https://ncbi.nlm.nih.gov/pubmed/17135187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkl944
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