Transient mismatch repair gene transfection for functional analysis of genetic hMLH1 and hMSH2 variants

Background: Germline mutations in the mismatch repair (MMR) genes hMLH1 and hMSH2 can cause hereditary non-polyposis colorectal cancer (HNPCC). However, the functional in vitro analysis of hMLH1 and hMSH2 mutations remains difficult. Aims: To establish an in vitro method for the functional character...

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Detaylı Bibliyografya
Asıl Yazarlar: Brieger, A, Trojan, J, Raedle, J, Plotz, G, Zeuzem, S
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BMJ Group 2002
Konular:
Gastrointestinal Cancer
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1773417/
https://ncbi.nlm.nih.gov/pubmed/12377806
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