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Transient mismatch repair gene transfection for functional analysis of genetic hMLH1 and hMSH2 variants
Background: Germline mutations in the mismatch repair (MMR) genes hMLH1 and hMSH2 can cause hereditary non-polyposis colorectal cancer (HNPCC). However, the functional in vitro analysis of hMLH1 and hMSH2 mutations remains difficult. Aims: To establish an in vitro method for the functional character...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BMJ Group
2002
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1773417/ https://ncbi.nlm.nih.gov/pubmed/12377806 |
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