The central cytoplasmic loop of the major facilitator superfamily of transport proteins governs efficient membrane insertion

Por Weinglass, Adam B., Kaback, H. Ronald
Publicado em 2000

Conformational flexibility at the substrate binding site in the lactose permease of Escherichia coli

Por Weinglass, Adam B., Kaback, H. Ronald
Publicado em 1999

Engineering a terbium-binding site into an integral membrane protein for luminescence energy transfer

Por Vázquez-Ibar, José Luis, Weinglass, Adam B., Kaback, H. Ronald
Publicado em 2002

Elucidation of substrate binding interactions in a membrane transport protein by mass spectrometry

Por Weinglass, Adam B., Whitelegge, Julian P., Hu, Yonglin, Verner, Gillian E., Faull, Kym F., Kaback, H.Ronald
Publicado em 2003

Extracellular loop C of NPC1L1 is important for binding to ezetimibe

Por Weinglass, Adam B., Kohler, Martin, Schulte, Uwe, Liu, Jessica, Nketiah, Emmanuel O., Thomas, Anu, Schmalhofer, William, Williams, Brande, Bildl, Wolfgang, McMasters, Daniel R., Dai, Kevin, Beers, Lindsey, McCann, Margaret E., Kaczorowski, Gregory J., Garcia, Maria L.
Publicado em 2008

GPR40 (FFAR1) – Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo

Por Hauge, Maria, Vestmar, Marie A., Husted, Anna S., Ekberg, Jeppe P., Wright, Michael J., Di Salvo, Jerry, Weinglass, Adam B., Engelstoft, Maja S., Madsen, Andreas N., Lückmann, Michael, Miller, Michael W., Trujillo, Maria E., Frimurer, Thomas M., Holst, Birgitte, Howard, Andrew D., Schwartz, Thue W.
Publicado no Mol Metab (2014)

GPR40 partial agonist MK-2305 lower fasting glucose in the Goto Kakizaki rat via suppression of endogenous glucose production

Por Miller, Corin, Pachanski, Michele J., Kirkland, Melissa E., Kosinski, Daniel T., Mane, Joel, Bunzel, Michelle, Cao, Jin, Souza, Sarah, Thomas-Fowlkes, Brande, Di Salvo, Jerry, Weinglass, Adam B., Li, Xiaoyan, Myers, Robert W., Knagge, Kevin, Carrington, Paul E., Hagmann, William K., Trujillo, Maria E.
Publicado no PLoS One (2017)

GPR120 suppresses adipose tissue lipolysis and synergizes with GPR40 in antidiabetic efficacy

Por Satapati, Santhosh, Qian, Ying, Wu, Margaret S., Petrov, Aleksandr, Dai, Ge, Wang, Sheng-ping, Zhu, Yonghua, Shen, Xiaolan, Muise, Eric S., Chen, Ying, Zycband, Emanuel, Weinglass, Adam, Di Salvo, Jerry, Debenham, John S., Cox, Jason M., Lan, Ping, Shah, Vinit, Previs, Stephen F., Erion, Mark, Kelley, David E., Wang, Liangsu, Howard, Andrew D., Shang, Jin
Publicado no J Lipid Res (2017)

GPR40 partial agonists and AgoPAMs: Differentiating effects on glucose and hormonal secretions in the rodent

Por Pachanski, Michele J., Kirkland, Melissa E., Kosinski, Daniel T., Mane, Joel, Cheewatrakoolpong, Boonlert, Xue, Jiyan, Szeto, Daphne, Forrest, Gail, Miller, Corin, Bunzel, Michelle, Plummer, Christopher W., Chobanian, Harry R., Miller, Michael W., Souza, Sarah, Thomas-Fowlkes, Brande S., Ogawa, Aimie M., Weinglass, Adam B., Di Salvo, Jerry, Li, Xiaoyan, Feng, Yue, Tatosian, Daniel A., Howard, Andrew D., Colletti, Steven L., Trujillo, Maria E.
Publicado no PLoS One (2017)

Design and Synthesis of Novel, Selective GPR40 AgoPAMs

Por Plummer, Christopher W., Clements, Matthew J., Chen, Helen, Rajagopalan, Murali, Josien, Hubert, Hagmann, William K., Miller, Michael, Trujillo, Maria E., Kirkland, Melissa, Kosinski, Daniel, Mane, Joel, Pachanski, Michele, Cheewatrakoolpong, Boonlert, Nolting, Andrew F., Orr, Robert, Christensen, Melodie, Campeau, Louis-Charles, Wright, Michael J., Bugianesi, Randal, Souza, Sarah, Zhang, Xiaoping, Di Salvo, Jerry, Weinglass, Adam B., Tschirret-Guth, Richard, Nargund, Ravi, Howard, Andrew D., Colletti, Steven L.
Publicado no ACS Med Chem Lett (2017)

Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation

Por Walsh, Shawn P., Shahripour, Aurash, Tang, Haifeng, Teumelsan, Nardos, Frie, Jessica, Zhu, Yuping, Priest, Birgit T., Swensen, Andrew M., Liu, Jessica, Margulis, Michael, Visconti, Richard, Weinglass, Adam, Felix, John P., Brochu, Richard M., Bailey, Timothy, Thomas-Fowlkes, Brande, Alonso-Galicia, Magdalena, Zhou, Xiaoyan, Pai, Lee-Yuh, Corona, Aaron, Hampton, Caryn, Hernandez, Melba, Bentley, Ross, Chen, Jing, Shah, Kashmira, Metzger, Joseph, Forrest, Michael, Owens, Karen, Tong, Vincent, Ha, Sookhee, Roy, Sophie, Kaczorowski, Gregory J., Yang, Lihu, Parmee, Emma, Garcia, Maria L., Sullivan, Kathleen, Pasternak, Alexander
Publicado no ACS Med Chem Lett (2015)

Design, Synthesis, and Evaluation of Novel and Selective G-protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists

Por Cox, Jason M., Chu, Hong D., Chelliah, Mariappan V., Debenham, John S., Eagen, Keith, Lan, Ping, Lombardo, Matthew, London, Clare, Plotkin, Michael A., Shah, Unmesh, Sun, Zhongxiang, Vaccaro, Henry M., Venkatraman, Srikanth, Suzuki, Takao, Wang, Nengxue, Ashley, Eric R., Crespo, Alejandro, Madeira, Maria, Leung, Dennis H., Alleyne, Candice, Ogawa, Aimie M., Souza, Sarah, Thomas-Fowlkes, Brande, Di Salvo, Jerry, Weinglass, Adam, Kirkland, Melissa, Pachanski, Michele, Powles, Mary Ann, Tozzo, Effie, Akiyama, Taro E., Ujjainwalla, Feroze, Tata, James R., Sinz, Christopher J.
Publicado no ACS Med Chem Lett (2016)