Subtype-selective sodium channel blockers promise a new era of pain research

Por Priest, Birgit T., Kaczorowski, Gregory J.
Publicado em 2007

Ion channels find a pathway for therapeutic success

Por Garcia, Maria L., Kaczorowski, Gregory J.
Publicado no Proc Natl Acad Sci U S A (2016)

Inactivation of the Phosphoenolpyruvate-Dependent Phosphotransferase System in Various Species of Bacteria by Vinylglycolic Acid

Por Snyder, Mark A., Kaczorowski, Gregory J., Barnes, Eugene M., Walsh, Christopher
Publicado em 1976

Ion Channels as Drug Targets: The Next GPCRs

Por Kaczorowski, Gregory J., McManus, Owen B., Priest, Birgit T., Garcia, Maria L.
Publicado em 2008

The Importance of Being Profiled: Improving Drug Candidate Safety and Efficacy Using Ion Channel Profiling

Por Kaczorowski, Gregory J., Garcia, Maria L., Bode, Jacob, Hess, Stephen D., Patel, Umesh A.
Publicado em 2011

Correolide, a nor-triterpenoid blocker of Shaker-type Kv1 channels elicits twitches in guinea-pig ileum by stimulating the enteric nervous system and enhancing neurotransmitter rel...

Por Vianna-Jorge, Rosane, Oliveira, Cyntia Ferreira, Garcia, Maria L, Kaczorowski, Gregory J, Suarez-Kurtz, Guilherme
Publicado em 2000

Shaker-type Kv1 channel blockers increase the peristaltic activity of guinea-pig ileum by stimulating acetylcholine and tachykinins release by the enteric nervous system

Por Vianna-Jorge, Rosane, Oliveira, Cyntia F, Garcia, Maria L, Kaczorowski, Gregory J, Suarez-Kurtz, Guilherme
Publicado em 2003

The β subunit of the high-conductance calcium-activated potassium channel contributes to the high-affinity receptor for charybdotoxin

Por Hanner, Markus, Schmalhofer, William A., Munujos, Petraki, Knaus, Hans-Günther, Kaczorowski, Gregory J., Garcia, Maria L.
Publicado em 1997

Functional Expression of Drosophila para Sodium Channels : Modulation by the Membrane Protein TipE and Toxin Pharmacology

Por Warmke, Jeffrey W., Reenan, Robert A.G., Wang, Peiyi, Qian, Su, Arena, Joseph P., Wang, Jixin, Wunderler, Denise, Liu, Ken, Kaczorowski, Gregory J., der Ploeg, Lex H.T. Van, Ganetzky, Barry, Cohen, Charles J.
Publicado em 1997

Contribution of the tetrodotoxin-resistant voltage-gated sodium channel Na(V)1.9 to sensory transmission and nociceptive behavior

Por Priest, Birgit T., Murphy, Beth A., Lindia, Jill A., Diaz, Carmen, Abbadie, Catherine, Ritter, Amy M., Liberator, Paul, Iyer, Leslie M., Kash, Shera F., Kohler, Martin G., Kaczorowski, Gregory J., MacIntyre, D. Euan, Martin, William J.
Publicado em 2005

Extracellular loop C of NPC1L1 is important for binding to ezetimibe

Por Weinglass, Adam B., Kohler, Martin, Schulte, Uwe, Liu, Jessica, Nketiah, Emmanuel O., Thomas, Anu, Schmalhofer, William, Williams, Brande, Bildl, Wolfgang, McMasters, Daniel R., Dai, Kevin, Beers, Lindsey, McCann, Margaret E., Kaczorowski, Gregory J., Garcia, Maria L.
Publicado em 2008

Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics

Por Tang, Haifeng, Walsh, Shawn P., Yan, Yan, de Jesus, Reynalda K., Shahripour, Aurash, Teumelsan, Nardos, Zhu, Yuping, Ha, Sookhee, Owens, Karen A., Thomas-Fowlkes, Brande S., Felix, John P., Liu, Jessica, Kohler, Martin, Priest, Birgit T., Bailey, Timothy, Brochu, Richard, Alonso-Galicia, Magdalena, Kaczorowski, Gregory J., Roy, Sophie, Yang, Lihu, Mills, Sander G., Garcia, Maria L., Pasternak, Alexander
Publicado em 2012

Improved Ca(v)2.2 Channel Inhibitors through a gem-Dimethylsulfone Bioisostere Replacement of a Labile Sulfonamide

Por Shao, Pengcheng P., Ye, Feng, Chakravarty, Prasun K., Herrington, James B., Dai, Ge, Bugianesi, Randal M., Haedo, Rodolfo J., Swensen, Andrew M., Warren, Vivien A., Smith, McHardy M., Garcia, Maria L., McManus, Owen B., Lyons, Kathryn A., Li, Xiaohua, Green, Mitchell, Jochnowitz, Nina, McGowan, Erin, Mistry, Shruti, Sun, Shu-Yu, Abbadie, Catherine, Kaczorowski, Gregory J., Duffy, Joseph L.
Publicado em 2013

Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure

Por Tang, Haifeng, Zhu, Yuping, Teumelsan, Nardos, Walsh, Shawn P., Shahripour, Aurash, Priest, Birgit T., Swensen, Andrew M., Felix, John P., Brochu, Richard M., Bailey, Timothy, Thomas-Fowlkes, Brande, Pai, Lee-Yuh, Hampton, Caryn, Corona, Aaron, Hernandez, Melba, Metzger, Joseph, Forrest, Michael, Zhou, Xiaoyan, Owens, Karen, Tong, Vincent, Parmee, Emma, Roy, Sophie, Kaczorowski, Gregory J., Yang, Lihu, Alonso-Galicia, Magdalena, Garcia, Maria L., Pasternak, Alexander
Publicado no ACS Med Chem Lett (2016)

Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation

Por Walsh, Shawn P., Shahripour, Aurash, Tang, Haifeng, Teumelsan, Nardos, Frie, Jessica, Zhu, Yuping, Priest, Birgit T., Swensen, Andrew M., Liu, Jessica, Margulis, Michael, Visconti, Richard, Weinglass, Adam, Felix, John P., Brochu, Richard M., Bailey, Timothy, Thomas-Fowlkes, Brande, Alonso-Galicia, Magdalena, Zhou, Xiaoyan, Pai, Lee-Yuh, Corona, Aaron, Hampton, Caryn, Hernandez, Melba, Bentley, Ross, Chen, Jing, Shah, Kashmira, Metzger, Joseph, Forrest, Michael, Owens, Karen, Tong, Vincent, Ha, Sookhee, Roy, Sophie, Kaczorowski, Gregory J., Yang, Lihu, Parmee, Emma, Garcia, Maria L., Sullivan, Kathleen, Pasternak, Alexander
Publicado no ACS Med Chem Lett (2015)