Extracellular loop C of NPC1L1 is important for binding to ezetimibe

Niemann–Pick C1-like protein (NPC1L1) mediates the absorption of dietary cholesterol in the proximal region of the intestine, a process that is blocked by cholesterol absorption inhibitors (CAIs), including ezetimibe (EZE). Using a proteomic approach, we demonstrate that NPC1L1 is the protein to whi...

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Detalhes bibliográficos
Main Authors: Weinglass, Adam B., Kohler, Martin, Schulte, Uwe, Liu, Jessica, Nketiah, Emmanuel O., Thomas, Anu, Schmalhofer, William, Williams, Brande, Bildl, Wolfgang, McMasters, Daniel R., Dai, Kevin, Beers, Lindsey, McCann, Margaret E., Kaczorowski, Gregory J., Garcia, Maria L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2516253/
https://ncbi.nlm.nih.gov/pubmed/18682566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800936105
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