Ion channels find a pathway for therapeutic success

Por Garcia, Maria L., Kaczorowski, Gregory J.
Publicado no Proc Natl Acad Sci U S A (2016)

Ion Channels as Drug Targets: The Next GPCRs

Por Kaczorowski, Gregory J., McManus, Owen B., Priest, Birgit T., Garcia, Maria L.
Publicado em 2008

Protein Surface Recognition by Rational Design: Nanomolar Ligands for Potassium Channels

Por Gradl, Stefan N., Felix, John P., Isacoff, Ehud Y., Garcia, Maria L., Trauner, Dirk
Publicado em 2003

The Importance of Being Profiled: Improving Drug Candidate Safety and Efficacy Using Ion Channel Profiling

Por Kaczorowski, Gregory J., Garcia, Maria L., Bode, Jacob, Hess, Stephen D., Patel, Umesh A.
Publicado em 2011

Correolide, a nor-triterpenoid blocker of Shaker-type Kv1 channels elicits twitches in guinea-pig ileum by stimulating the enteric nervous system and enhancing neurotransmitter rel...

Por Vianna-Jorge, Rosane, Oliveira, Cyntia Ferreira, Garcia, Maria L, Kaczorowski, Gregory J, Suarez-Kurtz, Guilherme
Publicado em 2000

Shaker-type Kv1 channel blockers increase the peristaltic activity of guinea-pig ileum by stimulating acetylcholine and tachykinins release by the enteric nervous system

Por Vianna-Jorge, Rosane, Oliveira, Cyntia F, Garcia, Maria L, Kaczorowski, Gregory J, Suarez-Kurtz, Guilherme
Publicado em 2003

The β subunit of the high-conductance calcium-activated potassium channel contributes to the high-affinity receptor for charybdotoxin

Por Hanner, Markus, Schmalhofer, William A., Munujos, Petraki, Knaus, Hans-Günther, Kaczorowski, Gregory J., Garcia, Maria L.
Publicado em 1997

Detection and Identification of Human Parainfluenza Viruses 1, 2, 3, and 4 in Clinical Samples of Pediatric Patients by Multiplex Reverse Transcription-PCR

Por Aguilar, Jose C., Pérez-Breña, María P., García, María L., Cruz, Nieves, Erdman, Dean D., Echevarría, Juan Emilio
Publicado em 2000

Detection and Identification of Human Parainfluenza Viruses 1, 2, 3, and 4 in Clinical Samples of Pediatric Patients by Multiplex Reverse Transcription-PCR

Por Aguilar, Jose C., Pérez-Breña, María P., García, María L., Cruz, Nieves, Erdman, Dean D., Echevarría, Juan Emilio
Publicado em 2000

Structural Determinants for Functional Coupling Between the β and α Subunits in the Ca(2+)-activated K(+) (BK) Channel

Por Orio, Patricio, Torres, Yolima, Rojas, Patricio, Carvacho, Ingrid, Garcia, Maria L., Toro, Ligia, Valverde, Miguel A., Latorre, Ramon
Publicado em 2006

Ten Years of Global Evolution of the Human Respiratory Syncytial Virus BA Genotype with a 60-Nucleotide Duplication in the G Protein Gene

Por Trento, Alfonsina, Casas, Inmaculada, Calderón, Ana, Garcia-Garcia, Maria L., Calvo, Cristina, Perez-Breña, Pilar, Melero, José A.
Publicado em 2010

Oxidative Regulation of Large Conductance Calcium-Activated Potassium Channels

Por Tang, Xiang D., Daggett, Heather, Hanner, Markus, Garcia, Maria L., McManus, Owen B., Brot, Nathan, Weissbach, Herbert, Heinemann, Stefan H., Hoshi, Toshinori
Publicado em 2001

Animal Assisted Therapy (AAT) Program As a Useful Adjunct to Conventional Psychosocial Rehabilitation for Patients with Schizophrenia: Results of a Small-scale Randomized Controlle...

Por Calvo, Paula, Fortuny, Joan R., Guzmán, Sergio, Macías, Cristina, Bowen, Jonathan, García, María L., Orejas, Olivia, Molins, Ferran, Tvarijonaviciute, Asta, Cerón, José J., Bulbena, Antoni, Fatjó, Jaume
Publicado no Front Psychol (2016)

Lacrimal Cytokines Assessment in Subjects Exposed to Different Levels of Ambient Air Pollution in a Large Metropolitan Area

Por Matsuda, Monique, Bonatti, Rodolfo, Marquezini, Mônica V., Garcia, Maria L. B., Santos, Ubiratan P., Braga, Alfésio L. F., Alves, Milton R., Saldiva, Paulo H. N., Monteiro, Mário L. R.
Publicado no PLoS One (2015)

Extracellular loop C of NPC1L1 is important for binding to ezetimibe

Por Weinglass, Adam B., Kohler, Martin, Schulte, Uwe, Liu, Jessica, Nketiah, Emmanuel O., Thomas, Anu, Schmalhofer, William, Williams, Brande, Bildl, Wolfgang, McMasters, Daniel R., Dai, Kevin, Beers, Lindsey, McCann, Margaret E., Kaczorowski, Gregory J., Garcia, Maria L.
Publicado em 2008

Discovery of Selective Small Molecule ROMK Inhibitors as Potential New Mechanism Diuretics

Por Tang, Haifeng, Walsh, Shawn P., Yan, Yan, de Jesus, Reynalda K., Shahripour, Aurash, Teumelsan, Nardos, Zhu, Yuping, Ha, Sookhee, Owens, Karen A., Thomas-Fowlkes, Brande S., Felix, John P., Liu, Jessica, Kohler, Martin, Priest, Birgit T., Bailey, Timothy, Brochu, Richard, Alonso-Galicia, Magdalena, Kaczorowski, Gregory J., Roy, Sophie, Yang, Lihu, Mills, Sander G., Garcia, Maria L., Pasternak, Alexander
Publicado em 2012

Improved Ca(v)2.2 Channel Inhibitors through a gem-Dimethylsulfone Bioisostere Replacement of a Labile Sulfonamide

Por Shao, Pengcheng P., Ye, Feng, Chakravarty, Prasun K., Herrington, James B., Dai, Ge, Bugianesi, Randal M., Haedo, Rodolfo J., Swensen, Andrew M., Warren, Vivien A., Smith, McHardy M., Garcia, Maria L., McManus, Owen B., Lyons, Kathryn A., Li, Xiaohua, Green, Mitchell, Jochnowitz, Nina, McGowan, Erin, Mistry, Shruti, Sun, Shu-Yu, Abbadie, Catherine, Kaczorowski, Gregory J., Duffy, Joseph L.
Publicado em 2013

Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure

Por Tang, Haifeng, Zhu, Yuping, Teumelsan, Nardos, Walsh, Shawn P., Shahripour, Aurash, Priest, Birgit T., Swensen, Andrew M., Felix, John P., Brochu, Richard M., Bailey, Timothy, Thomas-Fowlkes, Brande, Pai, Lee-Yuh, Hampton, Caryn, Corona, Aaron, Hernandez, Melba, Metzger, Joseph, Forrest, Michael, Zhou, Xiaoyan, Owens, Karen, Tong, Vincent, Parmee, Emma, Roy, Sophie, Kaczorowski, Gregory J., Yang, Lihu, Alonso-Galicia, Magdalena, Garcia, Maria L., Pasternak, Alexander
Publicado no ACS Med Chem Lett (2016)

Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation

Por Walsh, Shawn P., Shahripour, Aurash, Tang, Haifeng, Teumelsan, Nardos, Frie, Jessica, Zhu, Yuping, Priest, Birgit T., Swensen, Andrew M., Liu, Jessica, Margulis, Michael, Visconti, Richard, Weinglass, Adam, Felix, John P., Brochu, Richard M., Bailey, Timothy, Thomas-Fowlkes, Brande, Alonso-Galicia, Magdalena, Zhou, Xiaoyan, Pai, Lee-Yuh, Corona, Aaron, Hampton, Caryn, Hernandez, Melba, Bentley, Ross, Chen, Jing, Shah, Kashmira, Metzger, Joseph, Forrest, Michael, Owens, Karen, Tong, Vincent, Ha, Sookhee, Roy, Sophie, Kaczorowski, Gregory J., Yang, Lihu, Parmee, Emma, Garcia, Maria L., Sullivan, Kathleen, Pasternak, Alexander
Publicado no ACS Med Chem Lett (2015)

Multidrug Resistant Pulmonary Tuberculosis Treatment Regimens and Patient Outcomes: An Individual Patient Data Meta-analysis of 9,153 Patients

Por Ahuja, Shama D., Ashkin, David, Avendano, Monika, Banerjee, Rita, Bauer, Melissa, Bayona, Jamie N., Becerra, Mercedes C., Benedetti, Andrea, Burgos, Marcos, Centis, Rosella, Chan, Eward D., Chiang, Chen-Yuan, Cox, Helen, D'Ambrosio, Lia, DeRiemer, Kathy, Dung, Nguyen Huy, Enarson, Donald, Falzon, Dennis, Flanagan, Katherine, Flood, Jennifer, Garcia-Garcia, Maria L., Gandhi, Neel, Granich, Reuben M., Hollm-Delgado, Maria G., Holtz, Timothy H., Iseman, Michael D., Jarlsberg, Leah G., Keshavjee, Salmaan, Kim, Hye-Ryoun, Koh, Won-Jung, Lancaster, Joey, Lange, Christophe, de Lange, Wiel C. M., Leimane, Vaira, Leung, Chi Chiu, Li, Jiehui, Menzies, Dick, Migliori, Giovanni B., Mishustin, Sergey P., Mitnick, Carole D., Narita, Masa, O'Riordan, Philly, Pai, Madhukar, Palmero, Domingo, Park, Seung-kyu, Pasvol, Geoffrey, Peña, Jose, Pérez-Guzmán, Carlos, Quelapio, Maria I. D., Ponce-de-Leon, Alfredo, Riekstina, Vija, Robert, Jerome, Royce, Sarah, Schaaf, H. Simon, Seung, Kwonjune J., Shah, Lena, Shim, Tae Sun, Shin, Sonya S., Shiraishi, Yuji, Sifuentes-Osornio, José, Sotgiu, Giovanni, Strand, Matthew J., Tabarsi, Payam, Tupasi, Thelma E., van Altena, Robert, Van der Walt, Martie, Van der Werf, Tjip S., Vargas, Mario H., Viiklepp, Pirett, Westenhouse, Janice, Yew, Wing Wai, Yim, Jae-Joon
Publicado em 2012