Improved Ca(v)2.2 Channel Inhibitors through a gem-Dimethylsulfone Bioisostere Replacement of a Labile Sulfonamide

Por Shao, Pengcheng P., Ye, Feng, Chakravarty, Prasun K., Herrington, James B., Dai, Ge, Bugianesi, Randal M., Haedo, Rodolfo J., Swensen, Andrew M., Warren, Vivien A., Smith, McHardy M., Garcia, Maria L., McManus, Owen B., Lyons, Kathryn A., Li, Xiaohua, Green, Mitchell, Jochnowitz, Nina, McGowan, Erin, Mistry, Shruti, Sun, Shu-Yu, Abbadie, Catherine, Kaczorowski, Gregory J., Duffy, Joseph L.
Publicado em 2013

Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain

Por Chobanian, Harry R., Guo, Yan, Liu, Ping, Chioda, Marc D., Fung, Selena, Lanza, Thomas J., Chang, Linda, Bakshi, Raman K., Dellureficio, James P., Hong, Qingmei, McLaughlin, Mark, Belyk, Kevin M., Krska, Shane W., Makarewicz, Amanda K., Martel, Elliot J., Leone, Joseph F., Frey, Lisa, Karanam, Bindhu, Madeira, Maria, Alvaro, Raul, Shuman, Joyce, Salituro, Gino, Terebetski, Jenna L., Jochnowitz, Nina, Mistry, Shruti, McGowan, Erin, Hajdu, Richard, Rosenbach, Mark, Abbadie, Catherine, Alexander, Jessica P., Shiao, Lin-Lin, Sullivan, Kathleen M., Nargund, Ravi P., Wyvratt, Matthew J., Lin, Linus S., DeVita, Robert J.
Publicado em 2014