Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain

[Image: see text] We report herein the identification of MK-4409, a potent and selective fatty acid amide hydrolase (FAAH) inhibitor. Starting from a high throughput screening (HTS) hit, medicinal chemistry efforts focused on optimizing of FAAH inhibition in vitro potency, improving the pharmacokine...

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Główni autorzy: Chobanian, Harry R., Guo, Yan, Liu, Ping, Chioda, Marc D., Fung, Selena, Lanza, Thomas J., Chang, Linda, Bakshi, Raman K., Dellureficio, James P., Hong, Qingmei, McLaughlin, Mark, Belyk, Kevin M., Krska, Shane W., Makarewicz, Amanda K., Martel, Elliot J., Leone, Joseph F., Frey, Lisa, Karanam, Bindhu, Madeira, Maria, Alvaro, Raul, Shuman, Joyce, Salituro, Gino, Terebetski, Jenna L., Jochnowitz, Nina, Mistry, Shruti, McGowan, Erin, Hajdu, Richard, Rosenbach, Mark, Abbadie, Catherine, Alexander, Jessica P., Shiao, Lin-Lin, Sullivan, Kathleen M., Nargund, Ravi P., Wyvratt, Matthew J., Lin, Linus S., DeVita, Robert J.
Format: Artigo
Język:Inglês
Wydane: American Chemical Society 2014
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060928/
https://ncbi.nlm.nih.gov/pubmed/24944750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5001239
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