Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase

[Image: see text] We report herein the discovery of a fatty acid amide hydrolase (FAAH) positron emission tomography (PET) tracer. Starting from a pyrazole lead, medicinal chemistry efforts directed toward reducing lipophilicity led to the synthesis of a series of imidazole analogues. Compound 6 was...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Liu, Ping, Hamill, Terence G., Chioda, Marc, Chobanian, Harry, Fung, Selena, Guo, Yan, Chang, Linda, Bakshi, Raman, Hong, Qingmei, Dellureficio, James, Lin, Linus S., Abbadie, Catherine, Alexander, Jessica, Jin, Hong, Mandala, Suzanne, Shiao, Lin-Lin, Li, Wenping, Sanabria, Sandra, Williams, David, Zeng, Zhizhen, Hajdu, Richard, Jochnowitz, Nina, Rosenbach, Mark, Karanam, Bindhu, Madeira, Maria, Salituro, Gino, Powell, Joyce, Xu, Ling, Terebetski, Jenna L., Leone, Joseph F., Miller, Patricia, Cook, Jacquelynn, Holahan, Marie, Joshi, Aniket, O’Malley, Stacey, Purcell, Mona, Posavec, Diane, Chen, Tsing-Bau, Riffel, Kerry, Williams, Mangay, Hargreaves, Richard, Sullivan, Kathleen A., Nargund, Ravi P., DeVita, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027136/
https://ncbi.nlm.nih.gov/pubmed/24900701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4000996
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados