Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase

[Image: see text] We report herein the discovery of a fatty acid amide hydrolase (FAAH) positron emission tomography (PET) tracer. Starting from a pyrazole lead, medicinal chemistry efforts directed toward reducing lipophilicity led to the synthesis of a series of imidazole analogues. Compound 6 was...

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主要な著者: Liu, Ping, Hamill, Terence G., Chioda, Marc, Chobanian, Harry, Fung, Selena, Guo, Yan, Chang, Linda, Bakshi, Raman, Hong, Qingmei, Dellureficio, James, Lin, Linus S., Abbadie, Catherine, Alexander, Jessica, Jin, Hong, Mandala, Suzanne, Shiao, Lin-Lin, Li, Wenping, Sanabria, Sandra, Williams, David, Zeng, Zhizhen, Hajdu, Richard, Jochnowitz, Nina, Rosenbach, Mark, Karanam, Bindhu, Madeira, Maria, Salituro, Gino, Powell, Joyce, Xu, Ling, Terebetski, Jenna L., Leone, Joseph F., Miller, Patricia, Cook, Jacquelynn, Holahan, Marie, Joshi, Aniket, O’Malley, Stacey, Purcell, Mona, Posavec, Diane, Chen, Tsing-Bau, Riffel, Kerry, Williams, Mangay, Hargreaves, Richard, Sullivan, Kathleen A., Nargund, Ravi P., DeVita, Robert J.
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2013
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027136/
https://ncbi.nlm.nih.gov/pubmed/24900701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml4000996
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