Potential mechanism of enhanced postprandial glucagon‐like peptide‐1 release following treatment with a diacylglycerol acyltransferase 1 inhibitor

Por Liu, Jinqi, McLaren, David G., Chen, Dunlu, Kan, Yanqing, Stout, Steven J., Shen, Xiaolan, Murphy, Beth Ann, Forrest, Gail, Karanam, Bindhu, Sonatore, Lisa, He, Shuwen, Roddy, Thomas P., Pinto, Shirly
Publicado no Pharmacol Res Perspect (2015)

Identification and Characterization of Sebaceous Gland Atrophy-Sparing DGAT1 Inhibitors

Por Muise, Eric S., Zhu, Yonghua, Verras, Andreas, Karanam, Bindhu V., Gorski, Judith, Weingarth, Drew, Lin, Hua V., Hwa, Joyce, Thompson, John R., Hu, Guanghui, Liu, Jian, He, Shuwen, DeVita, Robert J., Shen, Dong-Ming, Pinto, Shirly
Publicado em 2014

Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes

Por Wu, Margaret, Singh, Sheo B., Wang, Jun, Chung, Christine C., Salituro, Gino, Karanam, Bindhu V., Lee, Sang Ho, Powles, Maryann, Ellsworth, Kenneth P., Lassman, Michael E., Miller, Corey, Myers, Robert W., Tota, Michael R., Zhang, Bei B., Li, Cai
Publicado em 2011

Discovery of Spirocyclic Aldosterone Synthase Inhibitors as Potential Treatments for Resistant Hypertension

Por Petrilli, Whitney L., Hoyt, Scott B., London, Clare, McMasters, Daniel, Verras, Andreas, Struthers, Mary, Cully, Doris, Wisniewski, Thomas, Ren, Ning, Bopp, Charlene, Sok, Andrea, Chen, Qing, Li, Ying, Tung, Elaine, Tang, Wei, Salituro, Gino, Knemeyer, Ian, Karanam, Bindhu, Clemas, Joseph, Zhou, Gaochao, Gibson, Jack, Shipley, Carrie Ann, MacNeil, Douglas J., Duffy, Ruth, Tata, James R., Ujjainwalla, Feroze, Ali, Amjad, Xiong, Yusheng
Publicado no ACS Med Chem Lett (2016)

Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety

Por He, Shuwen, Hong, Qingmei, Lai, Zhong, Wu, Zhicai, Yu, Yang, Kim, David W., Ting, Pauline C., Kuethe, Jeffrey T., Yang, Ginger X., Jian, Tianying, Liu, Jian, Guiadeen, Deodial, Krikorian, Arto D., Sperbeck, Donald M., Sonatore, Lisa M., Wiltsie, Judyann, Chung, Christine C., Gibson, Jack T., Lisnock, JeanMarie, Murphy, Beth A., Gorski, Judith N., Liu, Jinqi, Chen, Dunlu, Chen, Xiaoli, Wolff, Michael, Tong, Sharon X., Madeira, Maria, Karanam, Bindhu V., Shen, Dong-Ming, Balkovec, James M., Pinto, Shirly, Nargund, Ravi P., DeVita, Robert J.
Publicado em 2013

Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety

Por He, Shuwen, Hong, Qingmei, Lai, Zhong, Yang, David X., Ting, Pauline C., Kuethe, Jeffrey T., Cernak, Timothy A., Dykstra, Kevin D., Sperbeck, Donald M., Wu, Zhicai, Yu, Yang, Yang, Ginger X., Jian, Tianying, Liu, Jian, Guiadeen, Deodial, Krikorian, Arto D., Sonatore, Lisa M., Wiltsie, Judyann, Liu, Jinqi, Gorski, Judith N., Chung, Christine C., Gibson, Jack T., Lisnock, JeanMarie, Xiao, Jianying, Wolff, Michael, Tong, Sharon X., Madeira, Maria, Karanam, Bindhu V., Shen, Dong-Ming, Balkovec, James M., Pinto, Shirly, Nargund, Ravi P., DeVita, Robert J.
Publicado em 2014

Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain

Por Chobanian, Harry R., Guo, Yan, Liu, Ping, Chioda, Marc D., Fung, Selena, Lanza, Thomas J., Chang, Linda, Bakshi, Raman K., Dellureficio, James P., Hong, Qingmei, McLaughlin, Mark, Belyk, Kevin M., Krska, Shane W., Makarewicz, Amanda K., Martel, Elliot J., Leone, Joseph F., Frey, Lisa, Karanam, Bindhu, Madeira, Maria, Alvaro, Raul, Shuman, Joyce, Salituro, Gino, Terebetski, Jenna L., Jochnowitz, Nina, Mistry, Shruti, McGowan, Erin, Hajdu, Richard, Rosenbach, Mark, Abbadie, Catherine, Alexander, Jessica P., Shiao, Lin-Lin, Sullivan, Kathleen M., Nargund, Ravi P., Wyvratt, Matthew J., Lin, Linus S., DeVita, Robert J.
Publicado em 2014

Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase

Por Liu, Ping, Hamill, Terence G., Chioda, Marc, Chobanian, Harry, Fung, Selena, Guo, Yan, Chang, Linda, Bakshi, Raman, Hong, Qingmei, Dellureficio, James, Lin, Linus S., Abbadie, Catherine, Alexander, Jessica, Jin, Hong, Mandala, Suzanne, Shiao, Lin-Lin, Li, Wenping, Sanabria, Sandra, Williams, David, Zeng, Zhizhen, Hajdu, Richard, Jochnowitz, Nina, Rosenbach, Mark, Karanam, Bindhu, Madeira, Maria, Salituro, Gino, Powell, Joyce, Xu, Ling, Terebetski, Jenna L., Leone, Joseph F., Miller, Patricia, Cook, Jacquelynn, Holahan, Marie, Joshi, Aniket, O’Malley, Stacey, Purcell, Mona, Posavec, Diane, Chen, Tsing-Bau, Riffel, Kerry, Williams, Mangay, Hargreaves, Richard, Sullivan, Kathleen A., Nargund, Ravi P., DeVita, Robert J.
Publicado em 2013

Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes

Por Shah, Shrenik K., He, Shuwen, Guo, Liangqin, Truong, Quang, Qi, Hongbo, Du, Wu, Lai, Zhong, Liu, Jian, Jian, Tianying, Hong, Qingmei, Dobbelaar, Peter, Ye, Zhixiong, Sherer, Edward, Feng, Zhe, Yu, Yang, Wong, Frederick, Samuel, Koppara, Madiera, Maria, Karanam, Bindhu V., Reddy, Vijay B., Mitelman, Stan, Tong, Sharon X., Chicchi, Gary G., Tsao, Kwei-Lan, Trusca, Dorina, Feng, Yue, Wu, Margaret, Shao, Qing, Trujillo, Maria E., Eiermann, George J., Li, Cai, Pachanski, Michele, Fernandez, Guillermo, Nelson, Donald, Bunting, Patricia, Morissette, Pierre, Volksdorf, Sylvia, Kerr, Janet, Zhang, Bei B., Howard, Andrew D., Zhou, Yun-Ping, Pasternak, Alexander, Nargund, Ravi P., Hagmann, William K.
Publicado no ACS Med Chem Lett (2015)