Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety

[Image: see text] We report the design and synthesis of a series of novel DGAT1 inhibitors in the benzimidazole class with a pyridyl-oxy-cyclohexanecarboxylic acid moiety. In particular, compound 11A is a potent DGAT1 inhibitor with excellent selectivity against ACAT1. Compound 11A significantly red...

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Main Authors: He, Shuwen, Hong, Qingmei, Lai, Zhong, Wu, Zhicai, Yu, Yang, Kim, David W., Ting, Pauline C., Kuethe, Jeffrey T., Yang, Ginger X., Jian, Tianying, Liu, Jian, Guiadeen, Deodial, Krikorian, Arto D., Sperbeck, Donald M., Sonatore, Lisa M., Wiltsie, Judyann, Chung, Christine C., Gibson, Jack T., Lisnock, JeanMarie, Murphy, Beth A., Gorski, Judith N., Liu, Jinqi, Chen, Dunlu, Chen, Xiaoli, Wolff, Michael, Tong, Sharon X., Madeira, Maria, Karanam, Bindhu V., Shen, Dong-Ming, Balkovec, James M., Pinto, Shirly, Nargund, Ravi P., DeVita, Robert J.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2013
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027454/
https://ncbi.nlm.nih.gov/pubmed/24900745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400168h
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