Preclinical Characterization of the FAAH Inhibitor JNJ-42165279

[Image: see text] The pre-clinical characterization of the aryl piperazinyl urea inhibitor of fatty acid amide hydrolase (FAAH) JNJ-42165279 is described. JNJ-42165279 covalently inactivates the FAAH enzyme, but is highly selective with regard to other enzymes, ion channels, transporters, and recept...

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Udgivet i:ACS Med Chem Lett
Main Authors: Keith, John M., Jones, William M., Tichenor, Mark, Liu, Jing, Seierstad, Mark, Palmer, James A., Webb, Michael, Karbarz, Mark, Scott, Brian P., Wilson, Sandy J., Luo, Lin, Wennerholm, Michelle L., Chang, Leon, Rizzolio, Michele, Rynberg, Raymond, Chaplan, Sandra R., Breitenbucher, J. Guy
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2015
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677372/
https://ncbi.nlm.nih.gov/pubmed/26713105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00353
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