Preclinical Characterization of the FAAH Inhibitor JNJ-42165279

[Image: see text] The pre-clinical characterization of the aryl piperazinyl urea inhibitor of fatty acid amide hydrolase (FAAH) JNJ-42165279 is described. JNJ-42165279 covalently inactivates the FAAH enzyme, but is highly selective with regard to other enzymes, ion channels, transporters, and recept...

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I publikationen:ACS Med Chem Lett
Huvudupphovsmän: Keith, John M., Jones, William M., Tichenor, Mark, Liu, Jing, Seierstad, Mark, Palmer, James A., Webb, Michael, Karbarz, Mark, Scott, Brian P., Wilson, Sandy J., Luo, Lin, Wennerholm, Michelle L., Chang, Leon, Rizzolio, Michele, Rynberg, Raymond, Chaplan, Sandra R., Breitenbucher, J. Guy
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2015
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677372/
https://ncbi.nlm.nih.gov/pubmed/26713105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00353
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