Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate

[Image: see text] A series of aryl piperazinyl ureas that act as covalent inhibitors of fatty acid amide hydrolase (FAAH) is described. A potent and selective (does not inhibit FAAH-2) member of this class, JNJ-40355003, was found to elevate the plasma levels of three fatty acid amides: anandamide,...

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Hlavní autoři: Keith, John M., Apodaca, Rich, Tichenor, Mark, Xiao, Wei, Jones, William, Pierce, Joan, Seierstad, Mark, Palmer, James, Webb, Michael, Karbarz, Mark, Scott, Brian, Wilson, Sandy, Luo, Lin, Wennerholm, Michelle, Chang, Leon, Brown, Sean, Rizzolio, Michele, Rynberg, Raymond, Chaplan, Sandra, Breitenbucher, J. Guy
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2012
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025847/
https://ncbi.nlm.nih.gov/pubmed/24900385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300186g
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