Fatty Acid Amide Hydrolase Inhibition by JNJ‐42165279: A Multiple‐Ascending Dose and a Positron Emission Tomography Study in Healthy Volunteers

Inhibition of fatty acid amide hydrolase (FAAH) potentiates endocannabinoid activity and is hypothesized to have therapeutic potential for mood and anxiety disorders and pain. The clinical profile of JNJ‐42165279, an oral selective FAAH inhibitor, was assessed by investigating the pharmacokinetics,...

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Detalhes bibliográficos
Publicado no:Clin Transl Sci
Main Authors: Postnov, Andrey, Schmidt, Mark E., Pemberton, Darrel J., de Hoon, Jan, van Hecken, Anne, van den Boer, Maarten, Zannikos, Peter, van der Ark, Peter, Palmer, James A., Rassnick, Stef, Celen, Sofie, Bormans, Guy, van Laere, Koen
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039207/
https://ncbi.nlm.nih.gov/pubmed/29575526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12548
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