Phase 1, randomized, parallel-group, double-blind, placebo-controlled trial to evaluate the effects of erenumab (AMG 334) and concomitant sumatriptan on blood pressure in healthy v...

Por de Hoon, Jan, Van Hecken, Anne, Vandermeulen, Corinne, Herbots, Marissa, Kubo, Yumi, Lee, Ed, Eisele, Osa, Vargas, Gabriel, Gabriel, Kristin
Publicado no Cephalalgia (2018)

Pharmacokinetic-Pharmacodynamic Relationship of Erenumab (AMG 334) and Capsaicin-Induced Dermal Blood Flow in Healthy and Migraine Subjects

Por Vu, Thuy, Ma, Peiming, Chen, Jiyun Sunny, de Hoon, Jan, Van Hecken, Anne, Yan, Lucy, Wu, Liviawati Sutjandra, Hamilton, Lisa, Vargas, Gabriel
Publicado no Pharm Res (2017)

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the CGRP Binding Monoclonal Antibody LY2951742 (Galcanezumab) in Healthy Volunteers

Por Monteith, David, Collins, Emily C., Vandermeulen, Corinne, Van Hecken, Anne, Raddad, Eyas, Scherer, Joel C., Grayzel, David, Schuetz, Thomas J., de Hoon, Jan
Publicado no Front Pharmacol (2017)

The potent calcitonin gene-related peptide receptor antagonist, telcagepant, does not affect nitroglycerin-induced vasodilation in healthy men

Por Van der Schueren, Bart J, Blanchard, Rebecca, Murphy, M Gail, Palcza, John, De Lepeleire, Inge, Van Hecken, Anne, Depré, Marleen, de Hoon, Jan N
Publicado em 2011

Fatty Acid Amide Hydrolase Inhibition by JNJ‐42165279: A Multiple‐Ascending Dose and a Positron Emission Tomography Study in Healthy Volunteers

Por Postnov, Andrey, Schmidt, Mark E., Pemberton, Darrel J., de Hoon, Jan, van Hecken, Anne, van den Boer, Maarten, Zannikos, Peter, van der Ark, Peter, Palmer, James A., Rassnick, Stef, Celen, Sofie, Bormans, Guy, van Laere, Koen
Publicado no Clin Transl Sci (2018)

Inhibition of capsaicin-induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK-0974)

Por Sinclair, Simon R, Kane, Stefanie A, Van der Schueren, Bart J, Xiao, Alan, Willson, Kenneth J, Boyle, Janet, de Lepeleire, Inge, Xu, Yang, Hickey, Lisa, Denney, William S, Li, Chi-Chung, Palcza, John, Vanmolkot, Floris H M, Depré, Marleen, Van Hecken, Anne, Murphy, M Gail, Ho, Tony W, de Hoon, Jay N
Publicado em 2010

[(18)F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor

Por Burns, H. Donald, Van Laere, Koen, Sanabria-Bohórquez, Sandra, Hamill, Terence G., Bormans, Guy, Eng, Wai-si, Gibson, Ray, Ryan, Christine, Connolly, Brett, Patel, Shil, Krause, Stephen, Vanko, Amy, Van Hecken, Anne, Dupont, Patrick, De Lepeleire, Inge, Rothenberg, Paul, Stoch, S. Aubrey, Cote, Josee, Hagmann, William K., Jewell, James P., Lin, Linus S., Liu, Ping, Goulet, Mark T., Gottesdiener, Keith, Wagner, John A., de Hoon, Jan, Mortelmans, Luc, Fong, Tung M., Hargreaves, Richard J.
Publicado em 2007